Department of Clinical Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
APMIS. 2014 Jul;122(7):643-7. doi: 10.1111/apm.12209. Epub 2013 Dec 10.
We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years of age with a laboratory- confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non-severe group). The sIL-2r and endothelin-1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non-severe CCHF and the control group (p < 0.05). In addition, those with non-severe CCHF were also found to have a significantly higher sIL-2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL-2r and endothelin-1 levels, serum levels of both sIL-2r and endothelin-1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL-2r and endothelin-1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL-2r and endothelin-1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.
我们旨在评估血清可溶性白细胞介素 2 受体 (sIL-2r) 和内皮素-1 水平与克里米亚-刚果出血热 (CCHF) 患儿严重感染之间的关系。本研究纳入了 52 名年龄在 18 岁以下、经实验室确诊的 CCHF 患者和 38 名健康对照者。根据疾病严重程度，将患者分为两组（严重组和非严重组）。与非严重 CCHF 组和对照组相比，严重 CCHF 患者的 sIL-2r 和内皮素-1 水平明显更高（p<0.05）。此外，非严重 CCHF 患者的 sIL-2r 水平也明显高于对照组（p<0.001）。虽然 sIL-2r 和内皮素-1 水平之间存在正相关，但血清 sIL-2r 和内皮素-1 水平与血小板计数呈负相关。在 CCHF 患儿中，血清 sIL-2r 和内皮素-1 水平升高，且这种升高与疾病严重程度相关。在本研究中，我们通过预后得出结论，sIL-2r 和内皮素-1 血清水平可能存在相关性，噬血细胞性淋巴组织细胞增生症和内皮损伤可能导致疾病的发病机制。
