Parlak Emine, Ertürk Ayşe, Çağ Yasemin, Sebin Engin, Gümüşdere Musa
Department of Infectious Diseases and Clinical Microbiology, Atatürk University Faculty of Medicine Erzurum, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Faculty of Medicine Rize, Turkey.
Int J Clin Exp Med. 2015 Oct 15;8(10):18302-10. eCollection 2015.
Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. Its pathogenesis basically involves endothelial damage. The aim of this study was to determine serum IL2, IL6, IL 10 and 25 OH Vitamin D levels in patients with CCHF and also to reveal their role in the clinical course and prognosis of the disease. Diagnosis of CCHF was confirmed using the positive polymerase chain reaction (PCR) test and/or positive IgM antibody by enzyme-linked immunosorbent assay (ELISA). Serum IL-2, IL-6, IL-10 and total 25 OH Vitamin D levels were also measured using ELISA. Eighty CCHF patients and 110 healthy controls were enrolled. IL2, IL6 and IL10 levels were significantly higher in the patient group. IL 6 and IL 10 levels were significantly higher in the fatal group. There was a positive correlation between Vitamin D and AST (r=0.402; P<0.001), and another positive correlation between IL-6 and CK (r=0.714; P<0.001). High IL6 and L10 levels are a significant indicator of fatality. Cytokines are only one of the factors responsible for mortality. We conclude that the pathogenesis of the disease can be better understood by elucidating the complicated cytokine network.
克里米亚-刚果出血热（CCHF）是一种蜱传病毒性疾病。其发病机制主要涉及内皮损伤。本研究的目的是测定CCHF患者血清白细胞介素2（IL2）、白细胞介素6（IL6）、白细胞介素10（IL 10）和25-羟基维生素D水平，并揭示它们在疾病临床过程和预后中的作用。通过聚合酶链反应（PCR）检测呈阳性和/或酶联免疫吸附测定（ELISA）检测IgM抗体呈阳性来确诊CCHF。还使用ELISA测定血清IL-2、IL-6、IL-10和总25-羟基维生素D水平。纳入了80例CCHF患者和110例健康对照。患者组的IL2、IL6和IL10水平显著更高。致命组的IL 6和IL 10水平显著更高。维生素D与谷草转氨酶（AST）之间存在正相关（r=0.402；P<0.001），IL-6与肌酸激酶（CK）之间存在另一个正相关（r=0.714；P<0.001）。高IL6和IL10水平是死亡的重要指标。细胞因子只是导致死亡的因素之一。我们得出结论，通过阐明复杂的细胞因子网络可以更好地理解该疾病的发病机制。
