Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China; Cardiovascular Research Center, Anhui Medical University, Hefei 230601, China.
Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China; Cardiovascular Research Center, Anhui Medical University, Hefei 230601, China.
Cell Signal. 2014 Mar;26(3):521-7. doi: 10.1016/j.cellsig.2013.11.037. Epub 2013 Dec 7.
Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases. The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone acetyltransferases on chromatin remodeling and play essential roles in regulating gene transcription. In recent years, the role of HDACs in cardiac fibrosis initiation and progression, as well as the therapeutic effects of HDAC inhibitors, has been well studied. Moreover, numerous studies indicated that HDAC activity is associated with the development and progression of cardiac fibrosis. In this review, the innovative aspects of HDACs are discussed, with respect to biogenesis, their role in cardiac fibrosis. Furthermore, the potential applications of HDAC inhibitors in the treatment of cardiac fibrosis associated with fibroblast activation and proliferation.
心肌纤维化是心脏病中心脏重构的一个重要病理特征。心肌纤维化的分子机制尚不清楚。组蛋白去乙酰化酶（HDACs）是一种平衡组蛋白乙酰转移酶在染色质重塑中乙酰化活性的酶，在调节基因转录中起着重要作用。近年来，HDACs 在心肌纤维化的发生和发展中的作用以及 HDAC 抑制剂的治疗效果已得到充分研究。此外，许多研究表明，HDAC 活性与心肌纤维化的发展和进展有关。在这篇综述中，讨论了 HDACs 在生物发生方面的创新性，以及它们在心肌纤维化中的作用。此外，还讨论了 HDAC 抑制剂在治疗与成纤维细胞激活和增殖相关的心肌纤维化方面的潜在应用。
