交错突状细胞肉瘤的遗传学在某些情况下与朗格汉斯细胞组织细胞增生症有一些共同的变化。

The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases.

机构信息

Clarient/GE Healthcare, Aliso Viejo, CA; MD Anderson Cancer Center/University of Texas, Houston, TX.

出版信息

Ann Diagn Pathol. 2014 Feb;18(1):18-20. doi: 10.1016/j.anndiagpath.2013.10.003. Epub 2013 Oct 29.

DOI:10.1016/j.anndiagpath.2013.10.003

Abstract

Histiocytic disorders have been noted to have evidence of transdifferentiation; examples of cases with combinations of different lineages have been shown. In our index case, we identified interdigitating dendritic cell (IDC) differentiation in a case of Langerhans cell histiocytosis (LCH). Little is currently known about the genetics of IDC sarcoma (IDCS) because they are exceedingly rare. Using array comparative genomic hybridization (aCGH), we evaluated 4 cases of IDCS and compared them with our index case, as well as genetic abnormalities previously found in LCH. Four cases of paraffin-embedded samples of IDCS and 1 case of LCH with IDC differentiation were evaluated using aCGH. Array CGH results showed no abnormalities in a case of LCH with interdigitating cell differentiation. In 3 of 4 cases of IDCS, genetic abnormalities were identified; 1 case had no identifiable abnormalities. Interdigitating dendritic cell sarcoma case 1 had gains of 3q and 13q; IDCS case 2 had trisomy 12; IDCS case 3 had deletions of 7p, 12p, 16p, 18q, 19q, and 22q; and IDCS case 4 had no detectable abnormalities. Our index case, LCH with IDC differentiation, showed no abnormalities by aCGH. A number of LCH cases do not have detectable genetic abnormalities. In contrast, 3 of 4 cases of IDCS evaluated had identifiable abnormalities by aCGH. Furthermore, 2 of these shared abnormalities, albeit of large genetic regions, with published abnormalities seen in LCH. No recurrent abnormalities were identified in the IDCS cases. However, the possibility of a relationship between IDCS and LCH cannot be entirely excluded by these results.

摘要

组织细胞增多症已被证明存在转分化证据；已经显示出具有不同谱系组合的病例示例。在我们的索引病例中，我们在朗格汉斯细胞组织细胞增生症（LCH）中鉴定出交错树突状细胞（IDC）分化。由于 IDC 肉瘤（IDCS）极为罕见，因此目前对其遗传学知之甚少。我们使用阵列比较基因组杂交（aCGH）评估了 4 例 IDCS，并将其与我们的索引病例以及先前在 LCH 中发现的遗传异常进行了比较。使用 aCGH 评估了 4 例石蜡包埋的 IDCS 样本和 1 例具有 IDC 分化的 LCH。阵列 CGH 结果显示具有交错细胞分化的 LCH 病例无异常。在 4 例 IDCS 中有 3 例存在遗传异常，1 例无异常。IDCS 病例 1 存在 3q 和 13q 的增益；IDCS 病例 2 存在 12 三体；IDCS 病例 3 存在 7p、12p、16p、18q、19q 和 22q 的缺失；IDCS 病例 4 无明显异常。我们的索引病例，具有 IDC 分化的 LCH，通过 aCGH 无异常。许多 LCH 病例没有可检测到的遗传异常。相比之下，通过 aCGH 评估的 4 例 IDCS 中有 3 例存在可识别的异常。此外，这 2 例与已发表的 LCH 中的异常具有相同的异常，尽管是大的遗传区域。在 IDCS 病例中未发现重复异常。但是，这些结果不能完全排除 IDCS 和 LCH 之间存在关系的可能性。