O'Malley Dennis P, Agrawal Renuka, Grimm Kate E, Hummel Jennifer, Glazyrin Alexey, Dim Daniel C, Madhusudhana Sheshadri, Weiss Lawrence M
Clarient Pathology Services, Aliso Viejo, CA; MD Anderson Cancer Center, University of Texas, Houston, TX.
Clarient Pathology Services, Aliso Viejo, CA.
Ann Diagn Pathol. 2015 Jun;19(3):113-6. doi: 10.1016/j.anndiagpath.2015.02.008. Epub 2015 Mar 5.
BRAF V600E mutations have been reported in several histiocytic and dendritic cell neoplasms. In this case series, we report BRAF V600E-positive histiocytic and dendritic cell neoplasms in association with lymphomas and lymphoid proliferations. This is a review of cases with immunohistochemistry for BRAF V600E, with additional immunohistochemistry to categorize tumors. We report the first case of BRAF V600E-positive indeterminate cell tumor in association with angioimmunoblastic T-cell lymphoma. We also report a case of BRAF V600E-positive interdigitating dendritic cell sarcoma in a patient with positive B-cell polymerase chain reaction. It is unclear if these neoplasms developed as transdifferentiation of lymphoid neoplasms or if they developed independently. These cases illustrate the expanding spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors and suggest that attention should be paid to lymphomas for possible coincident presentation of these disorders.
BRAF V600E突变已在多种组织细胞和树突状细胞肿瘤中被报道。在本病例系列中，我们报告了BRAF V600E阳性的组织细胞和树突状细胞肿瘤与淋巴瘤及淋巴样增殖相关。这是一篇对BRAF V600E进行免疫组化检测的病例综述，并通过额外的免疫组化对肿瘤进行分类。我们报告了首例与血管免疫母细胞性T细胞淋巴瘤相关的BRAF V600E阳性不确定细胞肿瘤。我们还报告了1例B细胞聚合酶链反应阳性患者的BRAF V600E阳性指状突树突状细胞肉瘤。尚不清楚这些肿瘤是作为淋巴样肿瘤的转分化而发生，还是独立发生。这些病例说明了BRAF V600E阳性组织细胞和树突状细胞肿瘤谱的扩大，并提示应关注淋巴瘤，以发现这些疾病可能的同时出现情况。
