Endocrinology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheeba, Israel Mount Sinai Medical Center, New York, New York, USA Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy Endocrinology, National Cancer Institute, Fondazione G. Pascale, Naples, Italy Erasmus MC, Rotterdam, The Netherlands Department of Internal Medicine, Division of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands.
Endocr Relat Cancer. 2014 May 6;21(3):R153-63. doi: 10.1530/ERC-13-0125. Print 2014 Jun.
Based on the current medical literature, the worldwide incidence of neuroendocrine tumours (NETs) seems to have increased; however, a systematic literature overview is lacking. This study aimed to collect all available data on the incidence of gastroenteropancreatic (GEP)-NETs and characteristics of population to establish their epidemiology. A sensitive MEDLINE search was carried out. The papers were selected via a cascade process that restricted the initial pool of 7991 articles to 33, using predefined inclusion and exclusion criteria. Original articles evaluating the incidence of sporadic GEP-NETs in regional, institutional and national registries were considered. The majority of data originated from the US National Cancer Institute Surveillance, Epidemiology and End Results database and from national cancer registries in Western Europe. Generally, because of the retrospective nature of existing databases the outcomes of studies might be biased, which hinders the drawing of firm conclusions. The age-adjusted incidence of GEP-NETs has increased steadily over the past four decades (1973-2007), increasing 3.65-fold in the USA and 3.8- to 4.8-fold in the UK. Incidence has changed variably from one anatomical site to another. The greatest increase in incidence occurred for gastric and rectal NETs, while the smallest increase occurred for small intestine NETs. There were gender and racial differences, which differed site by site and, in some cases, changed over time. The incidence rates (IRs) of GEP-NETs have increased significantly in the last 40 years. Data are only available from North America, Western Europe and Japan. A site-by-site analysis revealed that the IRs of some NETs increased more than those of others.
基于目前的医学文献，世界各地神经内分泌肿瘤（NETs）的发病率似乎有所增加；然而，缺乏系统的文献综述。本研究旨在收集所有关于胃肠胰神经内分泌肿瘤（GEP-NETs）发病率和人群特征的可用数据，以确定其流行病学情况。进行了一项敏感的 MEDLINE 搜索。通过级联过程选择论文，该过程通过预定义的纳入和排除标准将最初的 7991 篇文章限制在 33 篇。评估区域性、机构性和国家性登记处散发 GEP-NET 发病率和人群特征的原始文章被认为是合格的。大多数数据来源于美国国家癌症研究所监测、流行病学和结果数据库以及西欧国家癌症登记处。由于现有数据库的回顾性性质，研究结果可能存在偏倚，这阻碍了得出确凿的结论。在过去的四十年中（1973-2007 年），GEP-NETs 的年龄调整发病率稳步上升，在美国增加了 3.65 倍，在英国增加了 3.8-4.8 倍。发病率在不同解剖部位之间有所不同。胃和直肠 NETs 的发病率增长最大，而小肠 NETs 的发病率增长最小。存在性别和种族差异，这些差异因部位而异，在某些情况下，随着时间的推移而变化。在过去的 40 年中，GEP-NETs 的发病率显著增加。数据仅可从北美、西欧和日本获得。对各部位的分析表明，一些 NETs 的发病率增加超过了其他 NETs。
