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[干燥综合征和特发性血小板减少性紫癜长期随访期间发生的胸腺黏膜相关淋巴组织(MALT)淋巴瘤;病例报告]

[Thymic mucosa-associated lymphoid tissue (MALT) lymphoma developing during long-term follow-up for Sjögren's syndrome and idiopathic thrombocytopenic purpura;report of a case].

作者信息

Sawada Takahiro, Machino Ryusuke, Ishii Mitsuhisa, Takeji Miyuki, Maeda Toshiharu

机构信息

Department of Thoracic Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan.

出版信息

Kyobu Geka. 2013 Nov;66(12):1105-8.

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare type of lymphoma that arises in small CD20-positive lymphocytes. We encountered a case of thymic MALT lymphoma treated with surgical intervention during long-term follow-up for Sjögren's syndrome and idiopathic thrombocytopenic purpura (ITP). Although symptomatic remission of Sjögren's syndrome and ITP had already been achieved, the levels of anti-SSA and anti-SSB antibodies remained high. Chronic stimulation by these antibodies may contribute to the development of MALT lymphoma. A careful follow-up may be indicated for this case with a complex immunological background.

摘要

黏膜相关淋巴组织(MALT)淋巴瘤是一种罕见的淋巴瘤,由小的CD20阳性淋巴细胞引发。我们遇到一例胸腺MALT淋巴瘤患者,该患者在对干燥综合征和特发性血小板减少性紫癜(ITP)进行长期随访期间接受了手术干预。尽管干燥综合征和ITP已实现症状缓解,但抗SSA和抗SSB抗体水平仍居高不下。这些抗体的慢性刺激可能促使MALT淋巴瘤的发生。对于这例具有复杂免疫背景的病例,可能需要进行密切随访。

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