Kinoshita Naoe, Ashizawa Kazuto, Abe Kuniko, Yamasaki Naoya, Nakamura Akihiro, Tagawa Tsutomu, Soda Hiroshi, Nagayasu Takeshi, Hayashi Tomayoshi
Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan.
Surg Today. 2008;38(5):436-9. doi: 10.1007/s00595-007-3644-z. Epub 2008 Apr 30.
A 68-year-old Japanese man with Sjögren's syndrome was pointed out to have a nodular shadow in the anterior mediastinum. The tumor was resected under video-assisted thoracoscopy and it was pathologically diagnosed to be thymic mucosa-associated lymphoid tissue (MALT) lymphoma. There has been no recurrence for 17 months after surgery. Mucosa-associated lymphoid tissue lymphoma of the thymus is rare, and its pathological diagnosis requires sufficient knowledge and experience. Since thymic MALT lymphoma is distinct from MALT lymphoma of other sites in several ways, including gene abnormalities and geographic distribution, an alternative oncogenic pathway and the influence of racial and/or environmental factors must be considered to be involved. However, since the number of reported thymic MALT lymphomas is limited, these issues are still unclear. The accumulation of further similar cases will help to elucidate various issues concerning thymic MALT lymphoma associated with Sjögren's syndrome.
一名68岁的日本干燥综合征男性患者被指出前纵隔有一个结节状阴影。该肿瘤在电视辅助胸腔镜下切除，病理诊断为胸腺黏膜相关淋巴组织（MALT）淋巴瘤。术后17个月无复发。胸腺黏膜相关淋巴组织淋巴瘤罕见，其病理诊断需要足够的知识和经验。由于胸腺MALT淋巴瘤在基因异常和地理分布等几个方面与其他部位的MALT淋巴瘤不同，必须考虑涉及另一种致癌途径以及种族和/或环境因素的影响。然而，由于报道的胸腺MALT淋巴瘤病例数量有限，这些问题仍不明确。更多类似病例的积累将有助于阐明与干燥综合征相关的胸腺MALT淋巴瘤的各种问题。
