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2013 年的 2 型糖尿病:肠道在葡萄糖稳态中的核心作用。

Type 2 diabetes mellitus in 2013: A central role of the gut in glucose homeostasis.

机构信息

Department of Internal Medicine, Catholic University of Rome, Largo A. Gemelli 8, 00168 Rome, Italy.

Department of Surgery, Università La Sapienza, Viale Regina Elena 324, 00195 Rome, Italy.

出版信息

Nat Rev Endocrinol. 2014 Feb;10(2):73-4. doi: 10.1038/nrendo.2013.241. Epub 2013 Dec 10.

DOI:10.1038/nrendo.2013.241
PMID:24322651
Abstract

Metabolic surgery has been proven to be effective in inducing remission of type 2 diabetes mellitus prior to any significant weight reduction. Studies in 2013 have investigated the mechanisms of action of these procedures and have highlighted a central role of the small intestine in the effects on glucose homeostasis.

摘要

代谢手术已被证明在显著减轻体重之前有效诱导 2 型糖尿病缓解。2013 年的研究调查了这些手术的作用机制,并强调了小肠在葡萄糖稳态影响中的核心作用。

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Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance.db/db 小鼠或胰岛素抵抗个体分泌的空肠蛋白会损害胰岛素信号,从而导致胰岛素抵抗。
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Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency.
上消化道热休克蛋白 HSP70 和 GRP78 促进胰岛素抵抗、高血糖和非酒精性脂肪性肝炎。
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