垂直袖状胃切除术在啮齿动物中的作用与胃饥饿素无关。
The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.
机构信息
Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, USA.
出版信息
Gastroenterology. 2013 Jan;144(1):50-52.e5. doi: 10.1053/j.gastro.2012.09.009. Epub 2012 Sep 17.
Abstract
Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.
摘要
胃饥饿素是一种刺激食欲的激素，其水平的降低被认为与袖状胃切除术（VSG）和 Roux-en-Y 胃旁路手术治疗肥胖症的部分效果有关。我们研究了这些手术后大鼠循环中酰基和去酰基胃饥饿素的水平。我们发现，基于酶联免疫吸附测定和质谱分析，VSG 术后血液胃饥饿素水平降低，但 Roux-en-Y 胃旁路术后没有降低。我们比较了 VSG 在胃饥饿素缺陷型小鼠和野生型小鼠中的作用对食物摄入、体重、膳食脂肪偏好和葡萄糖耐量的影响。我们发现，VSG 在每种品系中都产生了类似的效果。因此，胃饥饿素信号的降低似乎不是 VSG 产生这些效果所必需的。
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本文引用的文献
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