Nuschke Austin
Department of Pathology; University of Pittsburgh; Pittsburgh, PA USA.
Organogenesis. 2014 Jan 1;10(1):29-37. doi: 10.4161/org.27405. Epub 2013 Dec 10.
Chronic or non-healing skin wounds present an ongoing challenge in advanced wound care, particularly as the number of patients increases while technology aimed at stimulating wound healing in these cases remains inefficient. Mesenchymal stem cells (MSCs) have proved to be an attractive cell type for various cell therapies due to their ability to differentiate into various cell lineages, multiple donor tissue types, and relative resilience in ex-vivo expansion, as well as immunomodulatory effects during transplants. More recently, these cells have been targeted for use in strategies to improve chronic wound healing in patients with diabetic ulcers or other stasis wounds. Here, we outline several mechanisms by which MSCs can improve healing outcomes in these cases, including reducing tissue inflammation, inducing angiogenesis in the wound bed, and reducing scarring following the repair process. Approaches to extend MSC life span in implant sites are also examined.
慢性或难愈合皮肤伤口在高级伤口护理中一直是一项挑战，特别是随着患者数量的增加，而旨在刺激这些伤口愈合的技术仍然效率低下。间充质干细胞（MSCs）已被证明是各种细胞疗法中一种有吸引力的细胞类型，因为它们能够分化为各种细胞谱系、多种供体组织类型，在体外扩增时具有相对的韧性，以及在移植过程中的免疫调节作用。最近，这些细胞已被用于改善糖尿病溃疡或其他淤滞性伤口患者慢性伤口愈合的策略中。在这里，我们概述了MSCs在这些情况下改善愈合结果的几种机制，包括减轻组织炎症、诱导伤口床血管生成以及减少修复过程后的瘢痕形成。还研究了延长植入部位MSCs寿命的方法。
