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基于具有侧接 l-3,4-二羟基苯丙氨酸基团的小肽的新型细胞黏附水凝胶的酶促形成。

Enzymatic formation of a novel cell-adhesive hydrogel based on small peptides with a laterally grafted l-3,4-dihydroxyphenylalanine group.

机构信息

College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, 30 Puzhunan Road, Nanjing, Jiangsu, China. bingfanghe@ njut.edu.cn.

出版信息

Nanoscale. 2014;6(3):1277-80. doi: 10.1039/c3nr04528e.

DOI:10.1039/c3nr04528e
PMID:24322882
Abstract

We rationally designed a bioadhesive supramolecular hydrogel by introducing L-3,4-dihydroxylphenylalanine (DOPA) groups while properly integrating the enzymatic reactions and self-assembly processes. The effective presence of the catechol groups successfully promoted the adhesion and proliferation of human fibroblast cells.

摘要

我们通过引入 L-3,4-二羟基苯丙氨酸(DOPA)基团,同时合理整合酶反应和自组装过程,理性设计了一种具有生物黏附性的超分子水凝胶。儿茶酚基团的有效存在成功促进了人成纤维细胞的黏附和增殖。

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Controlling the Self-Assembly of Biomolecules into Functional Nanomaterials through Internal Interactions and External Stimulations: A Review.通过内部相互作用和外部刺激控制生物分子自组装成功能纳米材料:综述
Nanomaterials (Basel). 2019 Feb 18;9(2):285. doi: 10.3390/nano9020285.
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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.
超分子水凝胶剂与水凝胶:从软物质到分子生物材料
Chem Rev. 2015 Dec 23;115(24):13165-307. doi: 10.1021/acs.chemrev.5b00299. Epub 2015 Dec 8.
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In situ formation of adhesive hydrogels based on PL with laterally grafted catechol groups and their bonding efficacy to wet organic substrates.基于具有侧向接枝儿茶酚基团的聚乳酸形成原位粘附水凝胶及其与潮湿有机底物的粘结效果。
J Mater Sci Mater Med. 2015 Dec;26(12):273. doi: 10.1007/s10856-015-5608-y. Epub 2015 Oct 30.