Costanzo Luca, Campisano Maria Barbara, Capodanno Davide, Sole Andrea, Grasso Carmelo, Ragusa Mario, Ronsivalle Giuseppe, Tamburino Claudia, Tamburino Corrado, Di Pino Luigi
Division of Angiology, Cardiotoracovascular Department, Ferrarotto-Policlinic Hospital, University of Catania, Catania, Italy.
Catheter Cardiovasc Interv. 2014 Jun 1;83(7):1169-75. doi: 10.1002/ccd.25320. Epub 2013 Dec 23.
Numerous reports have shown the relationship between carotid artery atherosclerosis and coronary artery disease (CAD). However, the association between complex CAD evaluated by SYNTAX score (SxScore) and prevalence of carotid lesion (CL) has not been fully investigated. We sought to assess the prevalence of carotid atherosclerosis in patients with multivessel CAD assessed by SxScore and the relationship between SxScore severity and features of carotid atherosclerosis.
Subjects were 204 consecutive patients with multivessel CAD assessed by coronary angiography and no previous history of carotid atherosclerosis that underwent carotid ultrasound scan from June 2012 to 2013. Presence of CL, significant carotid disease (SCD) and carotid plaque morphology was evaluated. At least one CL was found in 159 patients (77.9%) with no significant difference among SxScore groups (P = 0.20 and P = 0.54, respectively). High prevalence of complex carotid plaque (CCP) was found without significant different distribution in SxScore groups (P = 0.69). Age was independently associated with the presence of CL [odds ratio (OR) 1.055; 95% confidence interval (CI): 1.015-1.097; P = 0.007] and SCD (OR 1.057; 95% CI: 1.008-1.097; P = 0.019). Age and diabetes were independently associated with CCP (OR 1.58; 95% CI: 1.023-1.095; P = 0.001; OR 1.848; 95% CI: 1.026-3.327; P = 0.041). SxScore was not independently associated with CL, SCD and CCP (all P > 0.2).
We found high prevalence of CL in patients with multivessel complex CAD. However, SxScore does not seem to correlate with carotid atherosclerosis.
众多报告已表明颈动脉粥样硬化与冠状动脉疾病（CAD）之间的关系。然而，通过SYNTAX评分（SxScore）评估的复杂CAD与颈动脉病变（CL）患病率之间的关联尚未得到充分研究。我们旨在评估通过SxScore评估的多支血管CAD患者中颈动脉粥样硬化的患病率，以及SxScore严重程度与颈动脉粥样硬化特征之间的关系。
研究对象为2012年6月至2013年期间连续纳入的204例经冠状动脉造影评估为多支血管CAD且既往无颈动脉粥样硬化病史的患者，这些患者均接受了颈动脉超声扫描。评估了CL的存在、显著颈动脉疾病（SCD）和颈动脉斑块形态。159例患者（77.9%）发现至少一处CL，在SxScore组之间无显著差异（分别为P = 0.20和P = 0.54）。发现复杂颈动脉斑块（CCP）的患病率较高，在SxScore组中的分布无显著差异（P = 0.69）。年龄与CL的存在独立相关[比值比（OR）1.055；95%置信区间（CI）：1.015 - 1.097；P = 0.007]以及与SCD独立相关（OR 1.057；95% CI：1.008 - 1.097；P = 0.019）。年龄和糖尿病与CCP独立相关（OR 1.58；95% CI：1.023 - 1.095；P = 0.001；OR 1.848；95% CI：1.026 - 3.327；P = 0.041）。SxScore与CL、SCD和CCP无独立相关性（所有P > 0.2）。
我们发现多支血管复杂CAD患者中CL的患病率较高。然而，SxScore似乎与颈动脉粥样硬化无关。
