Desvoyes Bénédicte, de Mendoza Alex, Ruiz-Trillo Iñaki, Gutierrez Crisanto
Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Nicolas Cabrera 1, 28049 Madrid, Spain
Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Catalonia, Spain.
J Exp Bot. 2014 Jun;65(10):2657-66. doi: 10.1093/jxb/ert411. Epub 2013 Dec 9.
The retinoblastoma (Rb) protein was identified as a human tumour suppressor protein that controls various stages of cell proliferation through the interaction with members of the E2F family of transcription factors. It was originally thought to be specific to animals but plants contain homologues of Rb, called RETINOBLASTOMA-RELATED (RBR). In fact, the Rb-E2F module seems to be a very early acquisition of eukaryotes. The activity of RBR depends on phosphorylation of certain amino acid residues, which in most cases are well conserved between plant and animal proteins. In addition to its role in cell-cycle progression, RBR has been shown to participate in various cellular processes such as endoreplication, transcriptional regulation, chromatin remodelling, cell growth, stem cell biology, and differentiation. Here, we discuss the most recent advances to define the role of RBR in cell proliferation and asymmetric cell division. These and other reports clearly support the idea that RBR is used as a landing platform of a plethora of cellular proteins and complexes to control various aspects of cell physiology and plant development.
视网膜母细胞瘤（Rb）蛋白被鉴定为一种人类肿瘤抑制蛋白，它通过与E2F转录因子家族成员相互作用来控制细胞增殖的各个阶段。最初认为它是动物特有的，但植物含有Rb的同源物，称为视网膜母细胞瘤相关蛋白（RBR）。事实上，Rb-E2F模块似乎是真核生物很早就获得的。RBR的活性取决于某些氨基酸残基的磷酸化，在大多数情况下，这些氨基酸残基在植物和动物蛋白之间高度保守。除了在细胞周期进程中的作用外，RBR还被证明参与各种细胞过程，如核内复制、转录调控、染色质重塑、细胞生长、干细胞生物学和分化。在这里，我们讨论了确定RBR在细胞增殖和不对称细胞分裂中作用的最新进展。这些以及其他报告清楚地支持了这样一种观点，即RBR被用作大量细胞蛋白和复合物的着陆平台，以控制细胞生理学和植物发育的各个方面。
