多糖胶囊的超声组装用于疏水性药物传递。
Sono-assembly of highly biocompatible polysaccharide capsules for hydrophobic drug delivery.
机构信息
Max Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany.
出版信息
Adv Healthc Mater. 2014 Jun;3(6):825-31. doi: 10.1002/adhm.201300596. Epub 2013 Dec 9.
PMID:24323846
Abstract
Cells like sugar. General synthesis and potential of intracellular hydrophobic drug delivery of single-component polysaccharide capsules are pursued. The capsules can be generally assembled through hydrogen bonding networks but show striking shell robustness. The evidenced cell internalization, stimuli-responsiveness to local pH changes and high biocompatibilities of the capsules specifically favor their potential intracellular drug delivery.
摘要
细胞喜欢糖。我们研究了单一组分多糖胶囊的一般合成方法及其在细胞内疏水性药物传递方面的潜力。这些胶囊通常可以通过氢键网络组装，但具有显著的壳坚固性。胶囊的细胞内化证据、对局部 pH 值变化的刺激响应性以及高生物相容性特别有利于它们在细胞内的药物传递。
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