细胞趋化因子及其受体在脑出血中的作用。
Chemokines and their receptors in intracerebral hemorrhage.
机构信息
Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, 11794-8651, USA.
出版信息
Transl Stroke Res. 2012 Jul;3(Suppl 1):70-9. doi: 10.1007/s12975-012-0155-z. Epub 2012 Apr 3.
Abstract
Intracerebral hemorrhage (ICH) is a devastating clinical event which results in a high rate of disability and death. At present, no effective treatment is available for ICH. Accumulating evidence suggests that inflammatory responses contribute significantly to the ICH-induced secondary brain outcomes. During ICH, inflammatory cells accumulate at the ICH site attracted by gradients of chemokines. This review summarizes recent progress in ICH studies and the chemoattractants that act during the injury and focuses on and introduces the basic biology of the chemokine monocyte chemoattractant protein-1 (MCP1) and its role in the progression of ICH. Better understanding of MCP1 signaling cascade and the compensation after its inhibition could shed light on the development of effective treatments for ICH.
摘要
脑出血（ICH）是一种破坏性的临床事件，导致高残疾率和死亡率。目前，ICH 没有有效的治疗方法。越来越多的证据表明，炎症反应对 ICH 引起的继发性脑损伤有重要影响。在 ICH 发生时，趋化因子梯度吸引炎症细胞聚集在 ICH 部位。本文综述了 ICH 研究的最新进展以及损伤过程中趋化因子的作用，并重点介绍了趋化因子单核细胞趋化蛋白-1（MCP1）的基本生物学特性及其在 ICH 进展中的作用。更好地理解 MCP1 信号级联及其抑制后的代偿作用可能为开发有效的 ICH 治疗方法提供思路。
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