Department of Neurosurgery, Georgia Health Sciences University, 1120 15th Street, Augusta, GA, 30912, USA,
Transl Stroke Res. 2012 Jul;3(Suppl 1):80-7. doi: 10.1007/s12975-012-0165-x. Epub 2012 Apr 14.
Intracerebral hemorrhage (ICH) is a debilitating neurological injury, accounting for 10-15 % of all strokes. Despite neurosurgical intervention and supportive care, the 30-day mortality rate remains ~50 %, with ICH survivors frequently displaying neurological impairments and requiring long-term assisted care. Unfortunately, the lack of medical interventions to improve clinical outcomes has led to the notion that ICH is the least treatable form of stroke. Hence, additional studies are warranted to better understand the pathophysiology of ICH. Astrogliosis is an underlying astrocytic response to a wide range of brain injuries and postulated to have both beneficial and detrimental effects. However, the molecular mechanisms and functional roles of astrogliosis remain least characterized following ICH. Herein, we review the functional roles of astrogliosis in brain injuries and raise the prospects of therapeutically targeting astrogliosis after ICH.
脑出血（ICH）是一种使人虚弱的神经损伤，占所有中风的 10-15%。尽管神经外科干预和支持性护理，30 天死亡率仍约为 50%，ICH 幸存者经常表现出神经损伤，并需要长期辅助护理。不幸的是，缺乏改善临床结果的医疗干预措施导致人们认为 ICH 是最难以治疗的中风形式。因此，需要进行更多的研究来更好地了解 ICH 的病理生理学。星形胶质细胞增生是一种广泛的脑损伤后的星形胶质细胞反应，据推测具有有益和有害的影响。然而，ICH 后星形胶质细胞增生的分子机制和功能作用仍最少被描述。在此，我们综述了星形胶质细胞增生在脑损伤中的功能作用，并提出了在 ICH 后靶向星形胶质细胞增生的治疗前景。
