Watson Noah, Bonsack Frederick, Sukumari-Ramesh Sangeetha
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Front Aging Neurosci. 2022 Apr 25;14:859067. doi: 10.3389/fnagi.2022.859067. eCollection 2022.
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high rates of mortality and morbidity. ICH patients often suffer devastating and debilitating neurological impairments, from which the majority of victims are unable to fully recover to functional independence. Unfortunately, there is no established medical therapy for ICH, which is partly attributed to the lack of understanding of the complex pathology of the disorder. Despite advanced age being a major risk factor of ICH, most preclinical studies on ICH employed young animal subjects. Due to this discrepancy, the molecular level changes in the aging brain after ICH are largely unknown, limiting the translation of preclinical studies into potential human treatments. The purpose of this review is to highlight the effects of advanced age on ICH- induced brain injury and recovery and to draw attention to current knowledge gaps, which warrant further investigation.
脑出血（ICH）是一种具有高死亡率和发病率的毁灭性中风亚型。脑出血患者常常遭受严重且使人衰弱的神经功能障碍，大多数患者无法完全恢复到功能独立状态。不幸的是，目前尚无针对脑出血的确立有效的医学治疗方法，部分原因是对该疾病复杂病理的认识不足。尽管高龄是脑出血的主要危险因素，但大多数关于脑出血的临床前研究使用的是年轻动物受试者。由于这种差异，脑出血后衰老大脑中的分子水平变化在很大程度上尚不明确，这限制了临床前研究向潜在人类治疗方法的转化。本综述的目的是强调高龄对脑出血所致脑损伤和恢复的影响，并提请注意当前的知识空白，这些空白值得进一步研究。
