信号转导 Na/K-ATPase 对肾功能和结构的调节。
Regulation of renal function and structure by the signaling Na/K-ATPase.
机构信息
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA.
出版信息
IUBMB Life. 2013 Dec;65(12):991-8. doi: 10.1002/iub.1229. Epub 2013 Dec 10.
Abstract
The Na/K-ATPase as an essential ion pump was discovered more than 50 years ago (Skou (1989) Biochim. Biophys. Acta 1000, 439-446; Feraille and Doucet (2001) Physiol. Rev. 81, 345-418). The signaling function of Na/K-ATPase has been gradually appreciated over the last 20 years, first from the studies of regulatory effects of ouabain on cardiac cell growth. Several reviews on this topic have been written during the last few years (Schoner and Scheiner-Bobis (2007) Am. J. Physiol. Cell. Physiol. 293, C509-C536; Xie and Cai (2003) Mol. Interv. 3, 157 - 168; Bagrov et al. (2009) Pharmacol. Rev. 61, 9-38; Tian and Xie (2008) Physiology 23, 205-211; Fontana et al. (2013) FEBS J. 280, 5450-5455; Blanco and Wallace (2013) Am. J. Physiol. Renal Physiol. 305, F797-F812). This article will focus on the molecular mechanism of Na/K-ATPase-mediated signal transduction and its potential regulatory role in renal physiology and diseases.
摘要
Na/K-ATPase 作为一种必需的离子泵，早在 50 多年前就被发现了（Skou（1989）Biochim. Biophys. Acta 1000, 439-446；Feraille 和 Doucet（2001）Physiol. Rev. 81, 345-418）。过去 20 年来，Na/K-ATPase 的信号转导功能逐渐被人们所认识，首先是从研究哇巴因对心肌细胞生长的调节作用开始的。近年来，有几篇关于这个主题的综述文章已经发表（Schoner 和 Scheiner-Bobis（2007）Am. J. Physiol. Cell. Physiol. 293, C509-C536；Xie 和 Cai（2003）Mol. Interv. 3, 157-168；Bagrov 等人（2009）Pharmacol. Rev. 61, 9-38；Tian 和 Xie（2008）Physiology 23, 205-211；Fontana 等人（2013）FEBS J. 280, 5450-5455；Blanco 和 Wallace（2013）Am. J. Physiol. Renal Physiol. 305, F797-F812）。本文将重点介绍 Na/K-ATPase 介导的信号转导的分子机制及其在肾脏生理学和疾病中的潜在调节作用。
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