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在胚胎神经视网膜中，c-src mRNA的积累受到发育调控。

Accumulation of c-src mRNA is developmentally regulated in embryonic neural retina.

作者信息

Vardimon L, Fox L E, Moscona A A

出版信息

Mol Cell Biol. 1986 Nov;6(11):4109-11. doi: 10.1128/mcb.6.11.4109-4111.1986.

DOI:10.1128/mcb.6.11.4109-4111.1986
PMID:2432396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367179/
Abstract

Accumulation of c-src mRNA gradually increased during early development of the neural retina in chicken embryos and reached a peak by days 11 to 13 of embryonic life. Thereafter, its amount declined to a low level which persisted also in adult retina. The early increase in c-src mRNA correlated inversely with the decrease in the amount of H3.2 replication histone mRNA and with the decline in the rate of cell growth. The accumulation profile of c-src mRNA corresponded to that of pp60c-src protein, suggesting that the latter is regulated at the level of transcription.

摘要

在鸡胚神经视网膜的早期发育过程中，c-src mRNA的积累逐渐增加，并在胚胎发育的第11至13天达到峰值。此后，其数量下降至低水平，在成年视网膜中也持续维持该水平。c-src mRNA的早期增加与H3.2复制组蛋白mRNA数量的减少以及细胞生长速率的下降呈负相关。c-src mRNA的积累情况与pp60c-src蛋白的积累情况相对应，这表明后者在转录水平受到调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/7ac4b86c90fe/molcellb00095-0555-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/52ffe9cc042b/molcellb00095-0554-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/beaf0cf7966a/molcellb00095-0554-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/7ac4b86c90fe/molcellb00095-0555-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/52ffe9cc042b/molcellb00095-0554-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/beaf0cf7966a/molcellb00095-0554-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20bd/367179/7ac4b86c90fe/molcellb00095-0555-a.jpg

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A chicken histone H3 gene contains intervening sequences.一个鸡组蛋白H3基因含有间隔序列。
Nature. 1982 Jun 3;297(5865):434-6. doi: 10.1038/297434a0.
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Expression of a cloned adenovirus gene is inhibited by in vitro methylation.克隆腺病毒基因的表达受到体外甲基化的抑制。
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Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.T 细胞激活过程中 pp56lck 的调节：对 src 样蛋白酪氨酸激酶的功能影响
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