在胚胎神经视网膜中，c-src mRNA的积累受到发育调控。
Accumulation of c-src mRNA is developmentally regulated in embryonic neural retina.
作者信息
Vardimon L, Fox L E, Moscona A A
出版信息
Mol Cell Biol. 1986 Nov;6(11):4109-11. doi: 10.1128/mcb.6.11.4109-4111.1986.
Abstract
Accumulation of c-src mRNA gradually increased during early development of the neural retina in chicken embryos and reached a peak by days 11 to 13 of embryonic life. Thereafter, its amount declined to a low level which persisted also in adult retina. The early increase in c-src mRNA correlated inversely with the decrease in the amount of H3.2 replication histone mRNA and with the decline in the rate of cell growth. The accumulation profile of c-src mRNA corresponded to that of pp60c-src protein, suggesting that the latter is regulated at the level of transcription.
摘要
在鸡胚神经视网膜的早期发育过程中，c-src mRNA的积累逐渐增加，并在胚胎发育的第11至13天达到峰值。此后，其数量下降至低水平，在成年视网膜中也持续维持该水平。c-src mRNA的早期增加与H3.2复制组蛋白mRNA数量的减少以及细胞生长速率的下降呈负相关。c-src mRNA的积累情况与pp60c-src蛋白的积累情况相对应，这表明后者在转录水平受到调控。
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