Foxp3⁺ T(reg) 细胞在体液免疫中的作用。
Foxp3⁺ T(reg) cells in humoral immunity.
机构信息
Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Osaka, Japan.
出版信息
Int Immunol. 2014 Feb;26(2):61-9. doi: 10.1093/intimm/dxt060. Epub 2013 Dec 9.
Abstract
T(reg) cells are essential for the maintenance of immune homeostasis and prevention of autoimmunity. In humoral immune responses, loss of T(reg) cell function causes increased levels of serum autoantibodies, hyper-IgE, spontaneous generation of germinal centres, and enhanced numbers of specialised T follicular helper cells (T(fh) cells) controlled by the lineage-defining transcription factor BCL-6 (B-cell lymphoma 6). Recent studies have demonstrated that a subset of T(reg) cells [T follicular regulatory (T(freg)) cells] are able to co-opt the follicular T-cell program by gaining expression of BCL-6 and travelling to the follicle where they have an important role in the control of expansion of T(fh) cells and the germinal centre reaction. However, the mechanisms by which they exert this control are still under investigation. In this review, we discuss the effects of T(reg) cells on humoral immunity and the mechanisms by which they exert their regulatory function.
摘要
T 细胞对于维持免疫稳态和预防自身免疫至关重要。在体液免疫反应中，T 细胞调节功能丧失会导致血清自身抗体水平升高、IgE 过度升高、生发中心自发产生以及由谱系定义转录因子 BCL-6（B 细胞淋巴瘤 6）控制的特化滤泡辅助 T 细胞（Tfh 细胞）数量增加。最近的研究表明，一部分 T 细胞（滤泡调节性 T 细胞[Tfreg 细胞]）通过获得 BCL-6 的表达并迁移到滤泡中，从而能够利用滤泡 T 细胞程序，在控制 Tfh 细胞扩增和生发中心反应方面发挥重要作用。然而，它们发挥这种控制作用的机制仍在研究中。在这篇综述中，我们讨论了 T 细胞对体液免疫的影响以及它们发挥调节功能的机制。
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