从白细胞介素 2 到白细胞介素 37：抗炎细胞因子的扩展谱。
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.
机构信息
Baylor Institute for Immunology Research, Dallas, Texas, USA.
出版信息
Nat Immunol. 2012 Oct;13(10):925-31. doi: 10.1038/ni.2406. Epub 2012 Sep 18.
Abstract
Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.
摘要
反馈调节回路由调节性 T 细胞（Treg 细胞）和抑制性细胞因子提供，是免疫系统的固有组成部分，与效应功能并存。在这里，我们将讨论一些已经进化出的调节细胞因子，它们允许机体对自身成分产生耐受性，同时清除病原体，而对宿主的潜在损伤最小。白细胞介素 2（IL-2）、IL-10 和转化生长因子-β（TGF-β）就是很好的例子，而 IL-27、IL-35 和 IL-37 则代表了抗炎细胞因子领域的新成员。我们还强调了通过体外和体内基因工程小鼠研究积累的信息如何有助于理解和治疗人类疾病。
相似文献
1
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.从白细胞介素 2 到白细胞介素 37：抗炎细胞因子的扩展谱。
Nat Immunol. 2012 Oct;13(10):925-31. doi: 10.1038/ni.2406. Epub 2012 Sep 18.
2
Th17 cells: from precursors to players in inflammation and infection.辅助性T细胞17：从前体细胞到炎症与感染中的参与者
Int Immunol. 2009 May;21(5):489-98. doi: 10.1093/intimm/dxp021. Epub 2009 Mar 4.
3
IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.白细胞介素-21通过调节调节性T细胞和辅助性T细胞17之间的平衡来调控实验性结肠炎。
Eur J Immunol. 2007 Nov;37(11):3155-63. doi: 10.1002/eji.200737766.
4
IL-17 and Th17 Cells.白细胞介素-17与辅助性T细胞17
Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710.
5
Regulatory T-cell-associated cytokines in systemic lupus erythematosus.系统性红斑狼疮中与调节性T细胞相关的细胞因子
J Biomed Biotechnol. 2011;2011:463412. doi: 10.1155/2011/463412. Epub 2011 Dec 18.
6
Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.前沿：白细胞介素-2和转化生长因子-β诱导产生的叉头框蛋白3阳性（Foxp3+）CD4阳性（CD4+）CD25阳性（CD25+）调节性T细胞对白细胞介素-6介导的向辅助性T细胞17（Th17）细胞的转化具有抗性。
J Immunol. 2008 Jun 1;180(11):7112-6. doi: 10.4049/jimmunol.180.11.7112.
7
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.白细胞介素-21启动一条诱导促炎性辅助性T细胞17（TH17）细胞的替代途径。
Nature. 2007 Jul 26;448(7152):484-487. doi: 10.1038/nature05970. Epub 2007 Jun 20.
8
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells.产生促炎细胞因子的Foxp3 +调节性T细胞的起源与功能
Cytokine. 2015 Nov;76(1):13-24. doi: 10.1016/j.cyto.2015.07.005. Epub 2015 Jul 10.
9
IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines.白细胞介素 35 是一种新型反应性抗炎细胞因子——一种新的抗炎细胞因子分类系统。
PLoS One. 2012;7(3):e33628. doi: 10.1371/journal.pone.0033628. Epub 2012 Mar 16.
10
Targeting the development and effector functions of TH17 cells.针对TH17细胞的发育和效应功能。
Semin Immunol. 2007 Dec;19(6):383-93. doi: 10.1016/j.smim.2007.10.016. Epub 2008 Jan 14.
引用本文的文献
1
Recombinant human bone morphogenetic protein-2 (rhBMP-2) induced macrophage biphasic polarization regulated by dexamethasone in vivo.重组人骨形态发生蛋白-2（rhBMP-2）在体内诱导巨噬细胞的双相极化受地塞米松调节。
Am J Transl Res. 2025 Jun 15;17(6):4159-4174. doi: 10.62347/UGHK3747. eCollection 2025.
2
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in lipopolysaccharide-induced neuroinflammation.白细胞介素-37在脂多糖诱导的神经炎症中通过髓样分化因子88/核因子-κB途径调节小胶质细胞表型并抑制炎症反应。
Inflamm Res. 2025 May 29;74(1):87. doi: 10.1007/s00011-025-02048-x.
3
Deep insight into cytokine storm: from pathogenesis to treatment.深入洞察细胞因子风暴：从发病机制到治疗。
Signal Transduct Target Ther. 2025 Apr 16;10(1):112. doi: 10.1038/s41392-025-02178-y.
4
Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy.间充质干细胞来源的细胞外囊泡可改善轻度肝损伤和轻微肝性脑病大鼠海马体中的神经炎症和神经传递以及认知障碍。
Stem Cell Res Ther. 2024 Dec 18;15(1):472. doi: 10.1186/s13287-024-04076-6.
5
Eimeria: Navigating complex intestinal ecosystems.艾美耳球虫：在复杂的肠道生态系统中导航。
PLoS Pathog. 2024 Nov 22;20(11):e1012689. doi: 10.1371/journal.ppat.1012689. eCollection 2024 Nov.
6
Immunological and cytokine profile (IL-25 and IL-35) in patients with infection in Southern Iraq.伊拉克南部 感染患者的免疫和细胞因子谱（IL-25 和 IL-35）。
Arch Razi Inst. 2024 Apr 30;79(2):315-320. doi: 10.32592/ARI.2024.79.2.315. eCollection 2024 Apr.
7
The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System.硒的免疫调节作用：从环境到人体免疫系统的探索。
Nutrients. 2024 Sep 30;16(19):3324. doi: 10.3390/nu16193324.
8
Circulating MicroRNAs and Cytokines Associated with Celiac Disease.与乳糜泻相关的循环微小RNA和细胞因子
Middle East J Dig Dis. 2024 Jul;16(3):185-192. doi: 10.34172/mejdd.2024.388. Epub 2024 Jul 31.
9
Dietary Supplementation with Naringin Improves Systemic Metabolic Status and Alleviates Oxidative Stress in Transition Cows via Modulating Adipose Tissue Function: A Lipid Perspective.柚皮苷膳食补充剂通过调节脂肪组织功能改善围产期奶牛的全身代谢状态并减轻氧化应激：脂质视角
Antioxidants (Basel). 2024 May 24;13(6):638. doi: 10.3390/antiox13060638.
10
Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation.自然白细胞介素-35（IL-35）诱导的调节性 T 细胞（Tr35）的适应性可塑性是 T 细胞免疫调节所必需的。
Theranostics. 2024 May 5;14(7):2897-2914. doi: 10.7150/thno.90608. eCollection 2024.
本文引用的文献
1
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways.通过相互依存的负调控途径层来抑制炎症信号。
Nat Immunol. 2012 Oct;13(10):916-24. doi: 10.1038/ni.2391. Epub 2012 Sep 18.
2
IL-12 family cytokines: immunological playmakers.白细胞介素-12 家族细胞因子：免疫调节因子。
Nat Immunol. 2012 Jul 19;13(8):722-8. doi: 10.1038/ni.2366.
3
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.Aiolos 通过直接沉默 Il2 表达来促进 TH17 分化。
Nat Immunol. 2012 Jul 1;13(8):770-7. doi: 10.1038/ni.2363.
4
IL-2: fine-tuning the germinal center reaction.白细胞介素 2：精细调节生发中心反应。
Immunity. 2012 May 25;36(5):702-4. doi: 10.1016/j.immuni.2012.05.005.
5
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation.白细胞介素-2 通过限制滤泡辅助 T 细胞分化来抑制生发中心形成。
Immunity. 2012 May 25;36(5):847-56. doi: 10.1016/j.immuni.2012.02.012. Epub 2012 Mar 29.
6
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.共生菌衍生信号调节嗜碱性粒细胞的生成和过敏炎症。
Nat Med. 2012 Mar 25;18(4):538-46. doi: 10.1038/nm.2657.
7
IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines.白细胞介素 35 是一种新型反应性抗炎细胞因子——一种新的抗炎细胞因子分类系统。
PLoS One. 2012;7(3):e33628. doi: 10.1371/journal.pone.0033628. Epub 2012 Mar 16.
8
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.功能不同的人 FOXP3+ Treg 细胞亚群，其表型类似于效应 Th 细胞。
Blood. 2012 May 10;119(19):4430-40. doi: 10.1182/blood-2011-11-392324. Epub 2012 Mar 21.
9
Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.通过异位胰腺β细胞表达白细胞介素-35预防自身免疫性糖尿病。
Diabetes. 2012 Jun;61(6):1519-26. doi: 10.2337/db11-0784. Epub 2012 Mar 16.
10
STAT5 is a potent negative regulator of TFH cell differentiation.STAT5 是 TFH 细胞分化的有效负调控因子。
J Exp Med. 2012 Feb 13;209(2):243-50. doi: 10.1084/jem.20111174. Epub 2012 Jan 23.
Zotero 插件