Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
Dis Markers. 2013;35(6):721-6. doi: 10.1155/2013/686027. Epub 2013 Nov 13.
The aim of this study was to evaluate the impact of the surgical excisional procedures for cervical intraepithelial neoplasia (CIN) treatment both on subsequent fertility (cervical factor) and pregnancy complication (risk of spontaneous preterm delivery). We retrospectively analyzed 236 fertile women who underwent conization for CIN. We included in the study 47 patients who carried on pregnancy and delivered a viable fetus. Patients were asked about postconization pregnancies, obstetrical outcomes, and a possible diagnosis of secondary infertility caused by cervical stenosis. We evaluated the depth of surgical excision, the timing between cervical conization and subsequent pregnancies, surgical technique, and maternal age at delivery. We recorded 47 deliveries, 10 cases of preterm delivery; 8 of them were spontaneous. The depth of surgical excision showed a statistically significant inverse correlation with gestational age at birth. The risk of spontaneous preterm delivery increased when conization depth exceeded a cut-off value of 1.5 cm. Our data do not demonstrated a relation between conization and infertility due to cervical stenosis.
本研究旨在评估宫颈上皮内瘤变（CIN）治疗的手术切除方法对随后的生育能力（宫颈因素）和妊娠并发症（自发性早产风险）的影响。我们回顾性分析了 236 例因 CIN 而行子宫颈锥形切除术的生育期妇女。我们纳入了 47 例妊娠并分娩活胎的患者。我们询问了患者锥切术后的妊娠情况、产科结局以及因宫颈狭窄导致继发性不孕的可能性诊断。我们评估了手术切除的深度、宫颈锥切术与随后妊娠之间的时间间隔、手术技术以及分娩时的母亲年龄。我们记录了 47 例分娩，10 例早产，其中 8 例为自发性早产。手术切除的深度与出生时的胎龄呈显著负相关。当锥切深度超过 1.5cm 的临界值时，自发性早产的风险增加。我们的数据并未显示宫颈锥形切除术与因宫颈狭窄导致的不孕之间存在关系。
