Buller R E, Jones H W
Am J Obstet Gynecol. 1982 Mar 1;142(5):506-12. doi: 10.1016/0002-9378(82)90752-9.
The effect of cone biopsy for cervical intraepithelial neoplasia on subsequent fertility and pregnancy was evaluated for 314 reproductive age women. Excluding patients lost to follow-up and those who had therapeutic hysterectomy, two study groups totaling 166 patients were obtained. The first consisted of 105 patients who did not become pregnant following conization. We found no evidence of secondary infertility caused by cervical conization. The second group of 61 patients achieved 88 pregnancies following conization. Comparison of these pregnancies with the outcome of 106 pregnancies by these same women prior to conization showed no effect of the operation on spontaneous abortions, preterm delivery, or cesarean section rates. The sole sequela of conization was to alter the duration of the first stage of labor.
对314名育龄妇女评估了宫颈锥切术治疗宫颈上皮内瘤变对后续生育能力和妊娠的影响。排除失访患者和接受治疗性子宫切除术的患者后，得到了两个研究组，共166例患者。第一组由105例锥切术后未怀孕的患者组成。我们没有发现宫颈锥切术导致继发性不孕的证据。第二组61例患者锥切术后共妊娠88次。将这些妊娠与这些妇女锥切术前106次妊娠的结局进行比较，结果显示手术对自然流产、早产或剖宫产率没有影响。锥切术唯一的后遗症是改变了第一产程的时长。
