Gharat Leena, Rathod Govind P, Kandalgaonkar Shilpa
Department of Oral Pathology & Microbiology, Maharana Pratap College Of Dentistry & Research Center, Gwalior, Madhya Pradesh, India.
J Int Oral Health. 2013 Oct;5(5):65-72. Epub 2013 Oct 26.
A specific association between cancer and the hemostatic system has been recognized for decades. Fibrinogen degradation product (FDP) is one of the factors, which opposes coagulation causing fibrinolysis. The mechanism of fibrinolysis can be used by the malignant cells to facilitate invasion into surrounding tissues and metastases to distant organs by breaking the fibrin barrier. The coagulation cascade also plays an important role in both the formation of tumour stroma and the promotion of hematogenous metastasis. The present study was undertaken to evaluate the serum FDP levels in individuals without any oral lesions and those with oral premalignant and malignant lesions, and determine whether the estimation of the same can be used as an aid in early diagnosis.
MATERIALS & METHODS: 25 cases each of Leukoplakia, Oral submucous fibrosis and Oral squamous cell carcinomas (OSCC) and normal control cases were selected. The OSCC cases were staged according to the TNM classification. Diagnosis of all cases was confirmed by histopathological examination. The aspirated serum was then subjected to the Thrombo-Wellco test which was used for the biochemical analysis of FDP.
Increased serum FDP levels were seen corresponding to the stage of the OSCC, but no appreciable difference was noted between the histological grades or in cases of premalignant lesions.
The study demonstrates that FDP levels correlate with the cancer stage and progression. Thus, the estimation of serum FDP levels can be used as a reliable prognostic indicator and as a biologic marker of tumour spread How to cite this article: Gharat L, Rathod GP. Quantitative estimation of Serum Fibrinogen Degradation Product levels in Oral Premalignant and Malignant lesions. J Int Oral Health 2013; 5(5):65-72.
癌症与止血系统之间的特定关联已被认识数十年。纤维蛋白原降解产物（FDP）是其中一个因素，它抑制凝血导致纤维蛋白溶解。恶性细胞可利用纤维蛋白溶解机制，通过破坏纤维蛋白屏障促进其侵入周围组织并转移至远处器官。凝血级联反应在肿瘤基质形成和血行转移促进过程中也起着重要作用。本研究旨在评估无任何口腔病变者、口腔癌前病变者及口腔恶性病变者的血清FDP水平，并确定对其进行检测是否有助于早期诊断。
选取25例白斑、口腔黏膜下纤维化、口腔鳞状细胞癌（OSCC）患者及正常对照者。OSCC患者根据TNM分类进行分期。所有病例均经组织病理学检查确诊。采集的血清随后进行血栓韦尔科试验，用于FDP的生化分析。
血清FDP水平随OSCC分期增加而升高，但在组织学分级之间或癌前病变病例中未观察到明显差异。
该研究表明FDP水平与癌症分期及进展相关。因此，血清FDP水平检测可作为可靠的预后指标及肿瘤扩散的生物学标志物。如何引用本文：Gharat L, Rathod GP. 口腔癌前病变和恶性病变中血清纤维蛋白原降解产物水平的定量评估。《国际口腔健康杂志》2013；5(5):65 - 72。
