Pereira Treville, Shetty Subraj, Pereira Svylvy
Department of Oral and Maxillofacial Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Sector 7, Nerul, India.
J Cancer Res Ther. 2015 Jan-Mar;11(1):78-82. doi: 10.4103/0973-1482.150352.
Tumor markers are the substances, which quantitatively change in serum, during tumor development. Tumor markers have now been introduced in the diagnosis of malignant lesions. One such tumor marker is serum lactate dehydrogenase (LDH). In the present study, an attempt was made to correlate the level of serum LDH with premalignant lesions/conditions and oral squamous cell carcinoma (OSCC).
This study was carried out to evaluate the role of serum LDH as a biochemical parameter in oral premalignant lesions/conditions and OSCC. Estimation of LDH level in serum was done by an autoanalyzer for spectrometry, and the Student's t-test was applied.
Increased levels of LDH were observed in serum; of patients with oral premalignant lesions and conditions, and OSCC. Increased serum LDH level had a positive correlation with the histologic grading of OSCC.
Serum LDH level can serve as a biochemical tool in assessing the malignant potential of premalignant lesions. Estimation of serum LDH may be used to screen the cases of oral malignancy as an adjunct to diagnosis.
肿瘤标志物是在肿瘤发生发展过程中血清中含量发生定量变化的物质。目前肿瘤标志物已被用于恶性病变的诊断。血清乳酸脱氢酶（LDH）就是这样一种肿瘤标志物。在本研究中，我们试图将血清LDH水平与癌前病变/状况及口腔鳞状细胞癌（OSCC）进行关联。
本研究旨在评估血清LDH作为口腔癌前病变/状况及OSCC生化参数的作用。采用自动分析仪通过光谱法测定血清中LDH水平，并应用Student's t检验。
在口腔癌前病变/状况患者及OSCC患者的血清中观察到LDH水平升高。血清LDH水平升高与OSCC的组织学分级呈正相关。
血清LDH水平可作为评估癌前病变恶性潜能的生化工具。血清LDH测定可作为辅助诊断手段用于筛查口腔恶性肿瘤病例。
