Campos-Mora Mauricio, Morales Rodrigo A, Gajardo Tania, Catalán Diego, Pino-Lagos Karina
Immune Regulation and Tolerance Research Group, Programa Disciplinario de Inmunología, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile , Santiago , Chile.
Front Immunol. 2013 Nov 25;4:405. doi: 10.3389/fimmu.2013.00405.
In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that seems to distinguish natural T regulatory (nTreg) cells, generated in the thymus, from inducible T regulatory (iTreg) cells raised in the periphery. Given the crucial role of both nTreg and iTreg cells in the generation and maintenance of immune tolerance, the ability to phenotypically identify each of these cell populations in vivo is needed to elucidate their biological properties. In turn, these properties have the potential to be developed for therapeutic use to promote immune tolerance. Here we describe the nature and functions of Nrp1, including its potential use as a therapeutic target in transplantation tolerance.
在免疫系统中，神经纤毛蛋白-1（Nrp1）是一种在树突状细胞（DC）和T细胞之间建立免疫突触过程中发挥重要作用的分子。最近，Nrp1已被确定为一种标志物，它似乎能够区分胸腺中产生的天然调节性T（nTreg）细胞和外周诱导产生的诱导性调节性T（iTreg）细胞。鉴于nTreg细胞和iTreg细胞在免疫耐受的产生和维持中都起着关键作用，因此需要在体内从表型上识别这些细胞群体中的每一种，以阐明它们的生物学特性。反过来，这些特性有可能被开发用于治疗，以促进免疫耐受。在此，我们描述了Nrp1的性质和功能，包括其作为移植耐受治疗靶点的潜在用途。
