Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile ; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001 Talca, Chile.
Evid Based Complement Alternat Med. 2013;2013:861786. doi: 10.1155/2013/861786. Epub 2013 Nov 13.
Platelets are no longer considered simply as cells participating in thrombosis. In atherosclerosis, platelets are regulators of multiple processes, with the recruitment of inflammatory cells towards the lesion sites, inflammatory mediators release, and regulation of endothelial function. The antiplatelet therapy has been used for a long time in an effort to prevent and treat cardiovascular diseases. However, limited efficacy in some patients, drug resistance, and side effects are limitations of current antiplatelet therapy. In this context, a large number of natural products (polyphenols, terpenoids, alkaloids, and fatty acids) have been reported with antiplatelet activity. In this sense, the present paper describes mechanisms of antiplatelet action of natural products on platelet P-selectin expression through cAMP levels and its role as peroxisome proliferator-activated receptors agonists.
血小板不再被简单地视为参与血栓形成的细胞。在动脉粥样硬化中，血小板是多种过程的调节剂，包括向病变部位募集炎症细胞、释放炎症介质以及调节内皮功能。抗血小板治疗已被长期用于预防和治疗心血管疾病。然而，在一些患者中疗效有限、药物耐药性和副作用是目前抗血小板治疗的局限性。在这种情况下，大量的天然产物（多酚、萜类、生物碱和脂肪酸）已被报道具有抗血小板活性。从这个意义上说，本文描述了天然产物通过 cAMP 水平对血小板 P-选择素表达的抗血小板作用机制及其作为过氧化物酶体增殖物激活受体激动剂的作用。
