在大鼠肿瘤中大量表达的一类新的类似长末端重复序列（LTR）的序列。
A new family of LTR-like sequences abundantly expressed in rat tumors.
作者信息
Suzuki N, Fujiyoshi T, Maehara Y, Takahashi K, Yamamoto M, Endo H
出版信息
Nucleic Acids Res. 1986 Dec 9;14(23):9271-89. doi: 10.1093/nar/14.23.9271.
We report the identification of two genome DNA fragments containing middle repetitive sequences abundantly expressed in various rat tumors but rarely in normal tissues. These fragments included homologous regions which belonged to a new family of long terminal repeat (LTR) like sequences, designated RAL elements; one displayed the solitary type and the other a provirus structure. The element was transcribed in a strand specific fashion and started from the presumptive cap site within the RAL element. The presumptive polyA addition site within the element was also utilized as evidence of the analysis of a cDNA clone containing the RAL element. This evidence suggested that transcriptional control signals within the element were functioning. Run on assay revealed that expression of the element was regulated at the transcriptional level.
我们报告了两个基因组DNA片段的鉴定结果，这些片段包含在各种大鼠肿瘤中大量表达但在正常组织中很少表达的中等重复序列。这些片段包括属于一个新的长末端重复（LTR）样序列家族的同源区域，命名为RAL元件；一个显示为单独类型，另一个为前病毒结构。该元件以链特异性方式转录，并从RAL元件内的假定帽位点开始。该元件内的假定多聚腺苷酸化位点也被用作分析包含RAL元件的cDNA克隆的证据。这一证据表明该元件内的转录控制信号在起作用。核连缀分析显示该元件的表达在转录水平受到调控。
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