主动脉瓣结钙化与缺血性脑卒中患者颅内狭窄的相关性。
Association of aortic knob calcification with intracranial stenosis in ischemic stroke patients.
机构信息
Department of Neurology, Wonkwang University School of Medicine, Wonkwang Institute of Clinical Medicine, Iksan, Korea.
出版信息
J Stroke. 2013 May;15(2):122-5. doi: 10.5853/jos.2013.15.2.122. Epub 2013 May 31.
BACKGROUND AND PURPOSE
Aortic knob calcification (AC) is associated with increased risks of cardiovascular and cerebrovascular events. We evaluated the clinical importance of AC in ischemic stroke patients with intracranial (IC) stenosis using simple, non-invasive and routine chest radiography.
METHODS
The presence of AC was assessed in a chest posteroanterior view in 307 acute ischemic stroke patients admitted from May 2009 to April 2010, and who underwent magnetic resonance angiography or distal subtraction angiography. The association of AC with IC stenosis was analyzed.
RESULTS
Patient age (68.3±8.7 vs. 65.9±8.27 years, P=0.04), and the prevalence of IC stenosis (70.7 vs. 41.3%, P<0.01) were higher in patients with AC than in patients without calcification. After adjusting for age, gender and vascular risk factors, logistic regression analysis showed that AC (Odds ratio, 3.54; 95% confidence interval, 1.90 to 6.61, P<0.01) and age (Odds ratio, 1.79; 95% confidence interval, 1.01 to 3.19; P=0.04) were independent factors affecting IC stenosis.
CONCLUSIONS
AC appears to be a reliable predictor for IC stenosis, an important mechanism of ischemic stroke.
背景与目的
主动脉结钙化（AC）与心血管和脑血管事件风险增加相关。我们通过简单、无创和常规的胸部 X 线摄影评估了颅内（IC）狭窄的缺血性脑卒中患者的 AC 的临床重要性。
方法
在 2009 年 5 月至 2010 年 4 月期间入院的 307 例急性缺血性脑卒中患者的胸部后前位 X 光片中评估了 AC 的存在，这些患者接受了磁共振血管造影或远端减影血管造影。分析了 AC 与 IC 狭窄的相关性。
结果
AC 患者的年龄（68.3±8.7 岁 vs. 65.9±8.27 岁，P=0.04）和 IC 狭窄的患病率（70.7% vs. 41.3%，P<0.01）均高于无钙化患者。在调整年龄、性别和血管危险因素后，逻辑回归分析显示 AC（优势比，3.54；95%置信区间，1.90 至 6.61，P<0.01）和年龄（优势比，1.79；95%置信区间，1.01 至 3.19；P=0.04）是影响 IC 狭窄的独立因素。
结论
AC 似乎是 IC 狭窄的可靠预测指标，是缺血性脑卒中的一个重要机制。
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