Department of ophthalmology, Eye and ENT Hospital, Key laboratory of myopia of State Health Ministry, Fudan University , Shanghai , PR China and.
Curr Eye Res. 2014 Mar;39(3):263-70. doi: 10.3109/02713683.2013.841259. Epub 2013 Dec 10.
To study the pachymetry map of the corneal epithelium in children wearing orthokeratology lenses automatically generated by a Fourier-domain optical coherence tomography.
The study was conducted on 60 children who had been fitted with myopic orthokeratology lenses. Patients were divided into two groups according to the duration of OK lens treatment (group 1: ≤14 days, n = 28; group 2: >14 days, n = 32). The control group consisted of 44 children. An FD-OCT device with a pachymetry module was used to map the central 6-mm corneal epithelial thickness. An epithelial thickness map was automatically generated and divided into three zones: central 2 mm, paracentral 2 to 5 mm (P1) and mid-peripheral 5 to 6 mm (P2). The average epithelial thickness of central (C), the temporal (T1), nasal (N1), superior (S1) and inferior (I1) sectors of P1, and the temporal (T2), nasal (N2), superior (S2) and inferior (I2) sectors of P2 were recorded and compared. The minimum and maximum points of epithelial thickness across the map were also recorded. Munnerlyn's formula was used to model the expected change in refractive error based on Δ(Max-Min) (Δ(Max-Min) = (Max-Min)study-(Max-Min) mean of control).
The central epithelial thickness was significantly different between individual groups and a significant difference from the control (Group 0) was seen in each treatment group. Both the epithelial thickness measurements of T1 and I1 were thinnest in Group 1. Both the epithelial thickness measurements of S2 and I2 were thickest in Group 2. The difference between maximum and minimum thickness was significantly different between groups with the largest effect in Group 2. The refractive changes predicted by Munnerlyn's formula were less than the actual refractive changes measured in both study groups.
The epithelial thickness map automatically generated by FD-OCT can provide regional information about corneal epithelium thickness following overnight wearing of OK lenses.
通过傅里叶域光学相干断层扫描自动生成角膜上皮的角膜地形图，研究佩戴角膜塑形镜的儿童的角膜上皮厚度。
本研究纳入了 60 名接受近视性角膜塑形镜治疗的儿童。根据角膜塑形镜治疗时间将患者分为两组（组 1：≤14 天，n=28；组 2：>14 天，n=32）。对照组由 44 名儿童组成。使用具有角膜地形图模块的 FD-OCT 设备来绘制中央 6mm 角膜上皮厚度。自动生成上皮厚度图，并将其分为三个区域：中央 2mm、旁中央 2 至 5mm（P1）和中周 5 至 6mm（P2）。记录并比较中央（C）、颞侧（T1）、鼻侧（N1）、上侧（S1）和下侧（I1）象限的上皮平均厚度以及 P1 的颞侧（T2）、鼻侧（N2）、上侧（S2）和下侧（I2）象限的上皮平均厚度。还记录了整个角膜上皮厚度图的最小和最大值。使用 Munnerlyn 公式基于 Δ(Max-Min)（Δ(Max-Min)=（Max-Min)study-(Max-Min) mean of control）来模拟预期的屈光度变化。
各组之间的中央上皮厚度存在显著差异，并且每个治疗组与对照组（组 0）相比均存在显著差异。在组 1 中，T1 和 I1 的上皮厚度测量值最薄。在组 2 中，S2 和 I2 的上皮厚度测量值最厚。各组之间最大和最小厚度之间的差异具有统计学意义，其中组 2 的差异最大。Munnerlyn 公式预测的屈光变化小于两组实际测量的屈光变化。
FD-OCT 自动生成的上皮厚度图可提供佩戴角膜塑形镜过夜后角膜上皮厚度的区域信息。
