Department of Ophthalmology, Eye and ENT Hospital, Fudan University; Key Laboratory of Myopia of The State Health Ministry, 200031, 83 Fenyang Road, Shanghai, People's Republic of China.
Sydney Eye Hospital, Sydney, NSW, 2000, Australia.
BMC Ophthalmol. 2020 Jun 19;20(1):240. doi: 10.1186/s12886-020-01477-y.
The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.
This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6 mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared.
Visual acuity and refraction improved significantly after OK lens wear. △ETFm thinned more than △ETSm (P = 0.027) at 1.5 mm in radius. △ETSm thickened more than △ETFm at 2.5 mm (P = 0.019) and 3.0 mm (P = 0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0 mm, 2.5 mm and 3.0 mm. ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5 mm.
Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.
本研究旨在探讨六个月过夜矫正近视角膜塑形术（OK）镜片佩戴后，散光角膜的主经线方向上角膜上皮厚度的变化。
这是一项前瞻性研究。57 名角膜散光屈光度达 1.50 屈光度（D）以下的患者佩戴球形 OK 镜片 6 个月。对 OK 镜片的适配度、视力、屈光度和角膜散光（CT）进行评估。使用傅里叶域光学相干断层扫描（FD-OCT）测量角膜 CT 直径 6mm 范围内主经线上的角膜上皮厚度（ET）。计算并比较同一直径上各子午线的 ET 差值均值（△ETSm 和△ETFm）。
OK 镜片佩戴后，视力和屈光度显著提高。在半径为 1.5mm 处，△ETFm 比△ETSm 变薄（P=0.027）。在半径为 2.5mm（P=0.019）和 3.0mm（P=0.036）处，△ETSm 比△ETFm 增厚更多。∣△ETSm-△ETFm∣与 2.0mm、2.5mm 和 3.0mm 处的基线中央 CT 显著相关。∣△ETSm-△ETFm∣与 2.5mm 处的基线周边 CT 显著相关。
过夜佩戴球形 OK 镜片会导致角膜散光眼角膜上皮厚度在陡峭和扁平子午线之间出现差异变化。
