Haque Sameena, Jones Lyndon, Simpson Trefford
Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada.
Optom Vis Sci. 2008 Oct;85(10):E963-76. doi: 10.1097/OPX.0b013e318188892c.
To measure corneal and epithelial thickness across four meridians using Optical Coherence Tomography (OCT) and to compare these measurements between normal non-lens wearers (NLW), rigid gas permeable (RGP) lens wearers, and RGP-wearing keratoconics (KC).
Both eyes of 60 subjects were measured (20 NLW, nine female:11 male, 27.6 +/- 5.9 years; 20 RGP, 20 female, 23.9 +/- 7.6 years; and 20 KC, seven female:13 male, 32.4 +/- 8.1 years). A customized fixation target employing LEDs in eight directions of gaze was attached to the OCT and corneal images obtained. Raw OCT scans were analyzed to yield values for corneal and epithelial thickness and color-coded maps were compiled.
Central corneal thickness (CCT) was thinnest in KC (447 +/- 68 microm) and similar between RGP (518 +/- 32 microm; pKC < 0.001) and NLW (517 +/- 21 microm) (p(KC) < 0.001 NLW pRGP > 0.05). Peripheral corneal thickness in NLW was thickest in the superior temporal and thinnest in the inferior (I) regions (superior temporal(thickest) vs. I(thinnest) p < 0.001). Central epithelial thickness was thinnest in KC (44 +/- 7 microm), followed by RGP (50 +/- 4 microm), then NLW (54 +/- 2 microm) (pKC < 0.001 NLW p(RGP) < 0.05). Central epithelial thickness in the KC group was significantly thinner than in the RGP group (p < 0.001). In the NLW group, peripheral epithelial thickness was thicker (63 +/- 5 microm) than central (p < 0.001) and was thickest in the superior (S) region and thinnest in the inferior (I) region (S(thickest) vs. I(thinnest) p < 0.001). KC epithelium was thinnest in the inferior temporal meridian (42 +/- 5 microm).
Thickness of the normal cornea and epithelium was greatest in the superior region. In all groups, the inferior cornea and epithelium was thinnest, and to a greater extent in the KC group.
使用光学相干断层扫描（OCT）测量四个子午线上的角膜厚度和上皮厚度，并比较正常非戴镜者（NLW）、硬性透气性（RGP）镜片佩戴者和佩戴RGP的圆锥角膜（KC）患者之间的这些测量值。
对60名受试者的双眼进行测量（20名NLW，9名女性：11名男性，27.6±5.9岁；20名RGP佩戴者，20名女性，23.9±7.6岁；20名KC患者，7名女性：13名男性，32.4±8.1岁）。将一个在八个注视方向使用发光二极管的定制固定目标附着在OCT上，并获取角膜图像。分析原始OCT扫描结果以得出角膜厚度和上皮厚度值，并编制彩色编码图。
圆锥角膜患者的中央角膜厚度（CCT）最薄（447±68微米），硬性透气性镜片佩戴者（518±32微米；pKC<0.001）和正常非戴镜者（517±21微米）之间相似（p（KC）<0.001，NLW与pRGP>0.05）。正常非戴镜者的周边角膜厚度在颞上区域最厚，在下区域最薄（颞上（最厚）与下（最薄），p<0.001）。中央上皮厚度在圆锥角膜患者中最薄（44±7微米），其次是硬性透气性镜片佩戴者（50±4微米），然后是正常非戴镜者（54±2微米）（pKC<0.001，NLW与p（RGP）<0.05）。圆锥角膜组的中央上皮厚度明显薄于硬性透气性镜片佩戴组（p<0.001）。在正常非戴镜者组中，周边上皮厚度比中央厚（63±5微米）（p<0.001），在上区域最厚，在下区域最薄（上（最厚）与下（最薄），p<0.001）。圆锥角膜上皮在颞下子午线最薄（42±5微米）。
正常角膜和上皮的厚度在上区域最大。在所有组中角膜和上皮在下区域最薄，在圆锥角膜组中程度更大。
