Medas Fabio, Calò Pietro Giorgio, Lai Maria Letizia, Tuveri Massimiliano, Pisano Giuseppe, Nicolosi Angelo
Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
J Med Case Rep. 2013 Dec 10;7:265. doi: 10.1186/1752-1947-7-265.
Metastatic neoplasms to the thyroid gland are rare in clinical practice. Clear cell renal carcinoma is the most frequent site of origin of thyroid metastases and represents 12 to 34% of all secondary thyroid tumors. Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. We report a case of clear cell renal carcinoma metastatic to a follicular adenoma. This is the tenth case of renal cell carcinoma metastasis to thyroid tumor reported in the literature.
A 62-year-old Caucasian woman with a history of clear cell renal carcinoma was admitted to our institution for multinodular goiter. A histological examination after total thyroidectomy revealed clear cell renal carcinoma metastasis to a thyroid follicular adenoma.
Preoperative diagnosis of secondary thyroid neoplasm is difficult to achieve. The diagnosis of metastatic disease should be taken into account if patients have a history of clear cell renal carcinoma or if there is a multifocal growth pattern and clear cell appearance of the cytoplasm.
在临床实践中，甲状腺转移性肿瘤较为罕见。透明细胞肾细胞癌是甲状腺转移瘤最常见的原发部位，占所有继发性甲状腺肿瘤的12%至34%。肿瘤-to-肿瘤转移极为罕见，即甲状腺肿瘤作为转移瘤的接受者。我们报告一例透明细胞肾细胞癌转移至滤泡性腺瘤的病例。这是文献报道的第十例肾细胞癌转移至甲状腺肿瘤的病例。
一名62岁有透明细胞肾细胞癌病史的白种女性因多结节性甲状腺肿入住我院。全甲状腺切除术后的组织学检查显示透明细胞肾细胞癌转移至甲状腺滤泡性腺瘤。
继发性甲状腺肿瘤的术前诊断很难实现。如果患者有透明细胞肾细胞癌病史，或者存在多灶性生长模式且细胞质呈透明细胞外观，则应考虑转移性疾病的诊断。
