Wang Zhaorui, Wang Jingjing, Pei Jing, Pan Yubo, Ding Rui
Department of Emergency Surgery, Lu 'an People's Hospital, Lu 'an Hospital Affiliated to Anhui Medical University, Lu 'an, Anhui, 237000, People's Republic of China.
Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.
Cancer Manag Res. 2024 Jun 4;16:575-583. doi: 10.2147/CMAR.S470045. eCollection 2024.
Commonly, the thyroid gland is regarded as an organ with fewer metastatic diseases, and colorectal metastasis to the thyroid (CMT) is rarely reported, especially, with that the clinical sign of thyroid metastasis nidus is the chief complaint. The CMT occurs in advanced colorectal cancer and is associated with poor prognosis and short survival.
In this case, we reported a patient with the sign of neck mass as the first manifestation of CMT. The patient underwent a partial thyroidectomy in June 2019, immunohistochemical findings of thyroid carcinoma suggested the possibility of adenocarcinoma of gastrointestinal tract. The patient underwent a colonoscopy in July 2019 and a colonic mass was found. Pathological examination diagnosed rectal adenocarcinoma. The patient underwent neoadjuvant chemotherapy, surgical treatment, postoperative adjuvant chemotherapy and targeted therapy. The patient died in June 2022.
The metastasis disease would not be ignored at all, when a patient complains at signs of neck mass. Further, the possibility of metastasis cancer should be considered once thyroid nodules occur in patients with colorectal cancer. Even though the biological characteristics and stage of the primary tumor have an important impact on the prognosis, positive standardized treatments can also be helpful.
通常，甲状腺被视为转移性疾病较少的器官，结直肠癌转移至甲状腺（CMT）的报道很少，尤其是以甲状腺转移病灶的临床症状为主诉的情况。CMT发生于晚期结直肠癌，与预后不良和生存期短相关。
在本病例中，我们报告了一名以颈部肿块为首发表现的CMT患者。该患者于2019年6月接受了甲状腺部分切除术，甲状腺癌的免疫组化结果提示为胃肠道腺癌的可能性。该患者于2019年7月接受了结肠镜检查，发现结肠肿块。病理检查诊断为直肠腺癌。该患者接受了新辅助化疗、手术治疗、术后辅助化疗和靶向治疗。患者于2022年6月死亡。
当患者主诉有颈部肿块症状时，转移疾病绝不能被忽视。此外，结直肠癌患者一旦出现甲状腺结节，应考虑转移癌的可能性。尽管原发肿瘤的生物学特性和分期对预后有重要影响，但积极规范的治疗也可能有所帮助。
