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玻璃体内抗 VEGF 药物是否有全身作用的证据，我们是否应该关注？

What is the evidence for systemic effects of intravitreal anti-VEGF agents, and should we be concerned?

出版信息

Br J Ophthalmol. 2014 Jun;98 Suppl 1(Suppl 1):i7-10. doi: 10.1136/bjophthalmol-2013-303844. Epub 2013 Dec 10.

DOI:10.1136/bjophthalmol-2013-303844
PMID:24326326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4033205/
Abstract

Anti-vascular endothelial growth factor (VEGF) therapy has revolutionised the treatment of retinal disease, and appears to be very safe. Nevertheless, there are several lines of evidence that imply that small doses of these agents could potentially have a systemic effect. The clinical significance of these systemic effects remains unclear, but further study is indicated.

摘要

抗血管内皮生长因子 (VEGF) 治疗已经彻底改变了视网膜疾病的治疗方法，而且似乎非常安全。然而，有几条证据线表明，这些药物的小剂量可能具有潜在的全身作用。这些全身作用的临床意义尚不清楚，但需要进一步研究。

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本文引用的文献

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Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial.抑制年龄相关性脉络膜新生血管中 VEGF 的替代治疗：IVAN 随机对照试验的 2 年发现。
Lancet. 2013 Oct 12;382(9900):1258-67. doi: 10.1016/S0140-6736(13)61501-9. Epub 2013 Jul 19.
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JAMA Ophthalmol. 2013 Aug;131(8):1099-101. doi: 10.1001/jamaophthalmol.2013.400.
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Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE.雷珠单抗治疗糖尿病黄斑水肿的长期疗效：两项 III 期临床试验（RISE 和 RIDE）的 36 个月结果。
Ophthalmology. 2013 Oct;120(10):2013-22. doi: 10.1016/j.ophtha.2013.02.034. Epub 2013 May 22.
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Incidence of choroidal neovascularization in the fellow eye in the comparison of age-related macular degeneration treatments trials.年龄相关性黄斑变性治疗试验中对侧眼脉络膜新生血管的发生率比较。
Ophthalmology. 2013 Oct;120(10):2035-41. doi: 10.1016/j.ophtha.2013.03.017. Epub 2013 May 22.
6
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Retina. 2012 Oct;32(9):1821-8. doi: 10.1097/IAE.0b013e31825db6ba.
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Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results.雷珠单抗和贝伐单抗治疗新生血管性年龄相关性黄斑变性：两年结果。
Ophthalmology. 2012 Jul;119(7):1388-98. doi: 10.1016/j.ophtha.2012.03.053. Epub 2012 May 1.