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在一名患有急性肠胃炎的7岁儿童中检测到Rotateq疫苗衍生的双重重配轮状病毒。

Detection of rotateq vaccine-derived, double-reassortant rotavirus in a 7-year-old child with acute gastroenteritis.

作者信息

Hemming Maria, Vesikari Timo

机构信息

From the *Vaccine Research Center, University of Tampere School of Medicine; and †Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

出版信息

Pediatr Infect Dis J. 2014 Jun;33(6):655-6. doi: 10.1097/INF.0000000000000221.

Abstract

We describe a case of acute gastroenteritis in a schoolgirl associated with a detection of vaccine-derived, human-bovine double reassortant G1P[8] rotavirus, without any known contact with recently vaccinated infants. We propose that human-bovine double reassortant G1P[8] may be formed in RotaTeq-vaccinated infants and can occasionally cause gastroenteritis symptoms in vaccine recipients who may rarely transmit the virus to close contacts. The present case suggests that such viruses can remain stable in environment longer than 1 transmission cycle.

摘要

我们描述了一名女学生患急性肠胃炎的病例,该病例与检测到疫苗衍生的人-牛双重重配G1P[8]轮状病毒有关,且她与近期接种疫苗的婴儿没有任何已知接触史。我们提出,人-牛双重重配G1P[8]可能在接种Rotateq疫苗的婴儿体内形成,并且偶尔会在疫苗接种者身上引起肠胃炎症状,而这些接种者可能很少将病毒传播给密切接触者。本病例表明,此类病毒在环境中可保持稳定超过1个传播周期。

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