Marcinek Klaudia, Zapolnik Paweł, Radziszewska Renata, Ochoda-Mazur Agnieszka, Czajka Hanna, Pawlik Dorota
Neonatology Clinical Department, University Hospital in Kraków, 31-501 Kraków, Poland.
College of Medical Sciences, University of Rzeszów, 35-315 Rzeszów, Poland.
Vaccines (Basel). 2023 Jul 26;11(8):1282. doi: 10.3390/vaccines11081282.
Preterm newborns are babies born before the end of the 36th week of gestational life. They are at increased risk of infection and death from infectious diseases. This is due, among other things, to the immaturity of the immune system and the long hospitalisation period. One common infectious disease in the paediatric population is rotavirus (RV) infection. We now have specific vaccines against this pathogen. The aim of this study was to evaluate the safety of rotavirus vaccination in the neonatal intensive care unit (NICU) setting and to determine the tolerance of this vaccine in low- and extremely low-weight children. The study carried out at a single centre, the University Hospital in Kraków, also allowed the assessment of vaccination trends during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. During the observation period, 126 premature newborns received the RV vaccine. We observed no adverse effects, and our analysis shows safety and good tolerance of the vaccine among preterm babies. In addition, we observed an increase in vaccination rates between 2019 and 2021, partly explained by parents' anxiety about infectious diseases in the era of pandemics and partly explained by a change in vaccination policy in Poland and the introduction of refunding for RV vaccination.
早产儿是指在妊娠36周结束前出生的婴儿。他们感染传染病以及因传染病死亡的风险更高。这尤其归因于免疫系统不成熟和住院时间长。儿科人群中一种常见的传染病是轮状病毒（RV）感染。我们现在有针对这种病原体的特定疫苗。本研究的目的是评估在新生儿重症监护病房（NICU）环境中接种轮状病毒疫苗的安全性，并确定该疫苗在低体重和极低体重儿童中的耐受性。在克拉科夫大学医院这一单一中心开展的这项研究，还能评估严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行期间的疫苗接种趋势。在观察期内，126名早产新生儿接种了RV疫苗。我们未观察到不良反应，我们的分析表明该疫苗在早产婴儿中具有安全性和良好的耐受性。此外，我们观察到2019年至2021年期间疫苗接种率有所上升，部分原因是父母在大流行时代对传染病的焦虑，部分原因是波兰疫苗接种政策的变化以及引入了RV疫苗接种退款。
