甲胎蛋白与白蛋白一级结构之间存在高度同源性的短序列。

Short sequences of high homology between the primary structures of alpha-fetoprotein and albumin.

作者信息

Moro R, Villacampa M J

出版信息

Tumour Biol. 1986;7(2-3):115-21.

Abstract

Several reports have shown a high percentage of homology between the primary structures of alpha-fetoprotein (AFP) and serum albumin (Alb). With the aid of a program which searches for all identical sequences, we compared the aminoacid sequence of AFP and Alb from several species. Two short pieces of very high homology were always present in all the AFPs and Albs studied, but in none of the other analyzed proteins. One is in Domain I (16 amino acids long) and the other in Domain III (17 residues long). The implications of this finding in relation to the function and evolution of AFP and Alb are discussed.

摘要

几份报告显示，甲胎蛋白（AFP）和血清白蛋白（Alb）的一级结构之间存在高度同源性。借助一个搜索所有相同序列的程序，我们比较了几种物种的AFP和Alb的氨基酸序列。在所有研究的AFP和Alb中，总是存在两段高度同源的短片段，但在其他分析的蛋白质中均未发现。一段在结构域I（16个氨基酸长），另一段在结构域III（17个残基长）。本文讨论了这一发现与AFP和Alb的功能及进化的关系。