Shi Qiuling, Duvic Madeleine, Osei Joyce S, Hordinsky Maria K, Norris David A, Price Vera H, Amos Christopher I, Christiano Angela M, Mendoza Tito R
Department of Symptom Research, M. D. Anderson Cancer Center, Houston, Texas, USA.
J Investig Dermatol Symp Proc. 2013 Dec;16(1):S49-50. doi: 10.1038/jidsymp.2013.18.
Alopecia areata (AA) is a nonscarring and recurrent disease characterized by hair loss that may significantly affect patient health-related quality of life (HRQoL). Given the lack of reliable and accurate reporting of HRQoL status in patients with AA, we analyzed data from 532 AA patients from the National Alopecia Areata Registry whose registry record included HRQoL assessments using three validated instruments: Skindex-16, brief version of the Fear of Negative Evaluation Scale, and Dermatology Life Quality Index. The mean HRQoL scores were compared with previously reported HRQoL levels from healthy controls and patients with other skin diseases. Two-step cluster analysis of Skindex-16 scales divided patients into two groups: 481 (57%) with good HRQoL and 361 (43%) with poor HRQoL. Multivariate logistic regression modeling revealed a set of risk factors for poor HRQoL: age <50 years (odds ratio (OR) 3.99, 95% confidence interval (CI) 1.66-9.58), female gender (OR 2.74, 95% CI 1.73-4.34), hair loss 25-99% (OR 2.47, 95% CI 1.12-5.45), family stress (OR 1.8, 95% CI 1.13-2.86), and job change (OR 2.01, 95% CI 1.02-3.94). The current analysis provides an overview of the HRQoL status of AA patients and may guide patient care in the future.
斑秃（AA）是一种非瘢痕性复发性疾病，其特征为脱发，这可能会显著影响患者的健康相关生活质量（HRQoL）。鉴于缺乏对斑秃患者HRQoL状况的可靠且准确的报告，我们分析了来自国家斑秃注册中心的532例斑秃患者的数据，其注册记录包括使用三种经过验证的工具进行的HRQoL评估：Skindex-16、消极评价恐惧量表简版和皮肤病生活质量指数。将HRQoL平均得分与先前报告的健康对照者和其他皮肤病患者的HRQoL水平进行比较。对Skindex-16量表进行两步聚类分析，将患者分为两组：481例（57%）HRQoL良好，361例（43%）HRQoL较差。多因素逻辑回归模型揭示了一组HRQoL较差的危险因素：年龄<50岁（比值比（OR）3.99，95%置信区间（CI）1.66 - 9.58）、女性（OR 2.74，95% CI 1.73 - 4.34）、脱发25% - 99%（OR 2.47，95% CI 1.12 - 5.45）、家庭压力（OR 1.8，95% CI 1.13 - 2.86）和工作变动（OR 2.01，95% CI 1.02 - 3.94）。当前分析概述了斑秃患者的HRQoL状况，并可能在未来指导患者护理。
