Mendoza Tito R, Osei Joyce S, Shi Qiuling, Duvic Madeleine
Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
J Investig Dermatol Symp Proc. 2013 Dec;16(1):S51-2. doi: 10.1038/jidsymp.2013.19.
The existing literature on alopecia areata (AA) clearly demonstrates patients' concerns related to physical symptoms, emotional well-being, mental health, social functioning, and other dimensions of daily functioning. Although questionnaires such as the Skindex-16 and the Dermatology Life Quality Index have been used, these questionnaires were validated for skin conditions other than AA as a chronic condition. The goals of this study are to develop a measure of quality of life, symptoms, and their impact for patients with AA called the Alopecia Areata Symptom Impact Scale (AASIS) and to provide psychometric evidence for its use. We used data from 1,400 patients from the National Alopecia Areata Registry together with clinical experts' reviews and quantitative approaches. The preliminary version of the AASIS with 13 items was administered to about 210 patients with AA. Results indicated that the AASIS measures three underlying constructs related to AA. These dimensions were impact of AA, hair loss, and physical skin symptoms. The internal consistency reliabilities of these subscales are 0.93, 0.86, and 0.81, respectively. Cognitive debriefing results showed that patients find the AASIS items easy to understand, clear, and concise. Preliminary evidence suggests that the AASIS is a reliable and valid measure of the symptoms and their impact in patients with AA.
现有关于斑秃（AA）的文献清楚地表明了患者对身体症状、情绪健康、心理健康、社会功能以及日常功能其他方面的担忧。尽管已经使用了诸如Skindex - 16和皮肤病生活质量指数等问卷，但这些问卷是针对除AA这种慢性病以外的其他皮肤状况进行验证的。本研究的目的是开发一种针对斑秃患者的生活质量、症状及其影响的测量工具，称为斑秃症状影响量表（AASIS），并为其使用提供心理测量学证据。我们使用了来自国家斑秃登记处的1400名患者的数据，以及临床专家的评审和定量方法。对大约210名斑秃患者施测了包含13个条目的AASIS初步版本。结果表明，AASIS测量了与斑秃相关的三个潜在结构。这些维度分别是斑秃的影响、脱发和皮肤身体症状。这些子量表的内部一致性信度分别为0.93、0.86和0.81。认知反馈结果显示，患者认为AASIS的条目易于理解、清晰且简洁。初步证据表明，AASIS是一种可靠且有效的测量斑秃患者症状及其影响的工具。
