Burns Laura J, Mesinkovska Natasha, Kranz Dory, Ellison Abby, Senna Maryanne M
Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
National Alopecia Areata Foundation, San Rafael, USA.
Int J Trichology. 2020 Sep-Oct;12(5):197-204. doi: 10.4103/ijt.ijt_99_20. Epub 2020 Nov 3.
Alopecia areata (AA), an unpredictable, nonscarring hair loss, is commonly perceived as a cosmetic, rather than medical, concern. However, substantial evidence exists describing the negative impact on quality of life, as the disease affects patients personally, socially, financially, and physically. Over time, the cumulative disability may perpetuate poor confidence, social disconnection, negative coping strategies, and failure to achieve a full life potential. Here, we describe the cumulative life course impairment (CLCI) of AA by examining the complex interaction of (1) stigmatization, (2) physical and psychiatric comorbidities, and (3) coping strategies. The model aggregates existing cross-sectional data, which have previously captured disease burden only as snapshots in time. Thus, by examining cumulative effects, the CLCI model serves as a proxy for longitudinal data to better describe life course epidemiology of the disease.
斑秃（AA）是一种不可预测的非瘢痕性脱发，通常被视为一个美容问题，而非医学问题。然而，大量证据表明，这种疾病会对患者的个人、社交、经济和身体状况产生负面影响，进而对生活质量造成不良影响。随着时间的推移，累积的残疾可能会使患者长期信心不足、社交隔离、采取消极的应对策略，并无法充分发挥生活潜力。在此，我们通过研究（1）污名化、（2）身体和精神共病以及（3）应对策略之间的复杂相互作用，来描述斑秃的累积生命历程损害（CLCI）。该模型汇总了现有的横断面数据，这些数据以前仅将疾病负担作为某个时间点的快照进行记录。因此，通过研究累积效应，CLCI模型可作为纵向数据的替代，以更好地描述该疾病的生命历程流行病学。
