通过 2-炔基苯胺与三氟甲硫基甲酰胺的反应合成 3-((三氟甲基)硫代)吲哚。
Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide.
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Chem Commun (Camb). 2014 Jan 18;50(5):578-80. doi: 10.1039/c3cc45958f. Epub 2013 Nov 25.
PMID:24326869
Abstract
3-((Trifluoromethyl)thio)indoles can be synthesized by a palladium(II)-catalyzed reaction of 2-alkynylaniline with trifluoromethanesulfanylamide in the presence of bismuth(III) chloride. The presence of bismuth(III) chloride is crucial for the success of this transformation, which activates the trifluoromethanesulfanylamide during the reaction.
摘要
3-((三氟甲基)硫代)吲哚可以通过钯(II)催化的 2-炔基苯胺与三氟甲硫酰胺在三氯化铋存在下的反应来合成。三氯化铋的存在对于这种转化的成功至关重要，它在反应过程中激活三氟甲硫酰胺。
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