Rothrauff Benjamin B, Tuan Rocky S
Center for Cellular and Molecular Engineering; Department of Orthopaedic Surgery; University of Pittsburgh School of Medicine; Pittsburgh, PA USA.
Organogenesis. 2014 Jan 1;10(1):13-28. doi: 10.4161/org.27404. Epub 2013 Dec 9.
The intrasynovial bone-tendon interface is a gradual transition from soft tissue to bone, with two intervening zones of uncalcified and calcified fibrocartilage. Following injury, the native anatomy is not restored, resulting in inferior mechanical properties and an increased risk of re-injury. Recent in vivo studies provide evidence of improved healing when surgical repair of the bone-tendon interface is augmented with cells capable of undergoing chondrogenesis. In particular, cellular therapy in bone-tendon healing can promote fibrocartilage formation and associated improvements in mechanical properties. Despite these promising results in animal models, cellular therapy in human patients remains largely unexplored. This review highlights the development and structure-function relationship of normal bone-tendon insertions. The natural healing response to injury is discussed, with subsequent review of recent research on cellular approaches for improved healing. Finally, opportunities for translating in vivo findings into clinical practice are identified.
滑膜内骨-肌腱界面是从软组织到骨的逐渐过渡，其间有两个未钙化和钙化纤维软骨的中间区域。损伤后，原始解剖结构无法恢复，导致力学性能下降和再次受伤风险增加。最近的体内研究表明，当用能够进行软骨形成的细胞增强骨-肌腱界面的手术修复时，愈合情况会得到改善。特别是，细胞疗法在骨-肌腱愈合中可促进纤维软骨形成并改善相关力学性能。尽管在动物模型中取得了这些有前景的结果，但人类患者的细胞疗法仍 largely unexplored。本综述重点介绍了正常骨-肌腱附着点的发育及其结构-功能关系。讨论了对损伤的自然愈合反应，随后回顾了关于改善愈合的细胞方法的最新研究。最后，确定了将体内研究结果转化为临床实践的机会。 （注：“largely unexplored”直译为“很大程度上未被探索”，这里意译为“仍在很大程度上未被研究”更通顺）
