Hammer C, Rath P-M, Steinmann J, Stoffels-Weindorf M, Klode J, Dissemond J
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland.
Hautarzt. 2014 Feb;65(2):148-52. doi: 10.1007/s00105-013-2728-5.
The toxin Panton-Valentine leukocidin (PVL) produced by S. aureus is known as a virulence factor that leads to severe infections of skin and soft tissue. However the effect of PVL on wound healing is not known yet. Therefore we examined the detection rate of PVL in patients with chronic wounds.
The study included 100 patients with chronic wounds of the lower limb. We determined in all S. aureus isolates the presence of the PVL gene using a PCR technique.
Altogether 94% of the patients had a leg ulcer, while 6% had a foot ulcer; 65% were women. PVL was found in two patients. One of the strains was methicillin-resistant (MRSA) and the other was methicillin-sensitive (MSSA).
In our investigation there was detection rate for PVL of 2% of all S. aureus isolates in patients with chronic wounds of the lower extremities. Although the role of PVL as a virulence factor of S. aureus in wound healing remains unclear, the detection of PVL should be taken as a cause for a consequent topical antimicrobial wound therapy because of the increased risk of serious infections.
金黄色葡萄球菌产生的杀白细胞毒素（PVL）是一种毒力因子，可导致皮肤和软组织的严重感染。然而，PVL对伤口愈合的影响尚不清楚。因此，我们检测了慢性伤口患者中PVL的检出率。
该研究纳入了100例下肢慢性伤口患者。我们使用聚合酶链反应（PCR）技术检测所有金黄色葡萄球菌分离株中PVL基因的存在情况。
共有94%的患者患有腿部溃疡，6%的患者患有足部溃疡；65%为女性。在两名患者中检测到PVL。其中一株对甲氧西林耐药（MRSA），另一株对甲氧西林敏感（MSSA）。
在我们的调查中，下肢慢性伤口患者中所有金黄色葡萄球菌分离株的PVL检出率为2%。尽管PVL作为金黄色葡萄球菌在伤口愈合中的毒力因子的作用仍不清楚，但由于严重感染风险增加，PVL的检测应被视为进行后续局部抗菌伤口治疗的一个原因。
