Zhu Feng, Jin Xiao-ping, Huang Mi-wu, Zhu Min, Chen Qiao-ling, Wang Feng, Hu Xiao-fei, Wang Wan-fen, Li Wei-ling, Li Cai, Zhu Zong-ya, Zheng Zhou
Department of Neurology, Taizhou Hospital Affiliated to Wenzhou Medical College, Taizhou, Zhejiang 317000, P.R. Chin.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Dec;30(6):711-5. doi: 10.3760/cma.j.issn.1003-9406.2013.06.017.
To assess the association between 2 single nucleotide polymorphisms (SNPs) located in exonic regions of matrix metalloproteinase-10 (MMP-10) gene and instability of carotid plaques in a Han Chinese population.
Five hundred and eighty-five patients were divided into carotid vulnerable plaque group (n=206) and stable plaque group (n=379) based on results of carotid B-mode ultrasonography. The SNPs were genotyped by real-time polymerase chain reaction using an ABI 7300 TaqMan platform.
The distribution of rs17435959 between the two groups was significantly different at both genotypic (GC+CC vs. GG, P=0.006, OR=2.012) and allelic levels (C vs. G, P=0.001,OR=2.160). Above differences have remained significant with binary logistic regression analysis (P=0.007, OR=2.022; P=0.002, OR=2.104). The minor allele frequency of rs17293607 was 0.56%.
Above findings suggested that rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque in ethnic Chinese Hans. The C allele may be a susceptible predictor for carotid vulnerable plaque.
