Department of Neurology, Taizhou Hospital, Affiliated Hospital of Wenzhou Medical College, Taizhou, Zhejiang, PR China.
Clin Chem Lab Med. 2011 Oct;49(10):1735-41. doi: 10.1515/CCLM.2011.241. Epub 2011 Jul 4.
Matrix metalloproteinase-7 (MMP-7) may play an important role in the development of vulnerable carotid plaque. An A-to-G transition (-181A/G) in the promoter region of MMP7 is functional in vitro by altering the transcriptional activity of the gene. The aim of this study was to investigate the association between the MMP7 -181A/G polymorphism and vulnerable carotid plaque formation.
The authors enrolled 641 patients and divided them into three groups according to the carotid ultrasound examination: vulnerable plaque group (n=118), stable plaque group (n=385) and no plaque group (n=138). Traditional atherosclerosis risk factors were recorded and the MMP7 -181A/G polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism.
In the multinomial logistic regression analysis, compared to the no plaque group, no relationship between MMP7 -181AG+GG genotypes and stable carotid plaque was observed [odds ratio (OR) 1.50; p=0.239]. However, the frequency of AG+GG genotypes was significantly higher in the vulnerable plaque group (OR 2.74; p=0.008). Age was a risk factor for plaque formation, while statin treatment can reduce the prevalence of atherosclerotic plaque. Additionally, using binary logistic regression analysis between the stable and vulnerable plaque groups, this MMP7 polymorphism was associated with vulnerable plaque independently of other factors [OR 1.83; 95% confidence interval 1.08- 3.11; p=0.026].
The MMP7 -181A/G polymorphism is associated with the development of vulnerable carotid plaques. Age is a risk factor for plaque formation, while statin therapy is associated with a decreased prevalence of carotid atheromatous plaques.
基质金属蛋白酶-7（MMP-7）可能在易损颈动脉斑块的形成中发挥重要作用。MMP7 启动子区域的 A 到 G 转换（-181A/G）在体外通过改变基因的转录活性具有功能。本研究旨在探讨 MMP7-181A/G 多态性与易损颈动脉斑块形成的关系。
作者纳入 641 例患者，根据颈动脉超声检查将其分为三组：易损斑块组（n=118）、稳定斑块组（n=385）和无斑块组（n=138）。记录传统的动脉粥样硬化危险因素，并通过聚合酶链反应-限制性片段长度多态性对 MMP7-181A/G 多态性进行基因分型。
在多项逻辑回归分析中，与无斑块组相比，MMP7-181AG+GG 基因型与稳定颈动脉斑块之间无相关性[比值比（OR）1.50；p=0.239]。然而，易损斑块组 AG+GG 基因型的频率明显更高（OR 2.74；p=0.008）。年龄是斑块形成的危险因素，而他汀类药物治疗可以降低动脉粥样硬化斑块的发生率。此外，在稳定斑块组和易损斑块组之间使用二元逻辑回归分析，该 MMP7 多态性与其他因素独立相关，是易损斑块的一个危险因素[OR 1.83；95%置信区间 1.08-3.11；p=0.026]。
MMP7-181A/G 多态性与易损颈动脉斑块的发生有关。年龄是斑块形成的危险因素，而他汀类药物治疗与颈动脉粥样硬化斑块的发生率降低有关。
