1University of East London, London, UK.
J Psychopharmacol. 2014 Jan;28(1):55-61. doi: 10.1177/0269881113515061. Epub 2013 Dec 10.
The recreational drug MDMA (3,4-methylenedioxymethamphetamine) or 'Ecstasy' is associated with heightened psychiatric distress and feelings of depression. The Drugs and Infancy Study (DAISY) monitored the psychiatric symptom profiles of mothers who used Ecstasy/MDMA while pregnant, and followed them over the first year post-partum.
We compared 28 young women whom took MDMA during their pregnancy with a polydrug control group of 68 women who took other psychoactive drugs while pregnant. The Brief Symptom Inventory (BSI) was completed for several periods: The first trimester of pregnancy; and 1, 4 and 12 months after childbirth. Recreational drug use was monitored at each time point.
During the first trimester of pregnancy, MDMA-using mothers reported higher depression scores than the polydrug controls. At 1 year after childbirth, their BSI depression scores were significantly lower, now closer to the control group values. At the same time point, their self-reported use of MDMA became nearly zero, in contrast to their continued use of Cannabis/marijuana, nicotine and alcohol. We found significant symptom reductions in those with BSI obsessive-compulsive and interpersonal sensitivity, following Ecstasy/MDMA cessation.
The findings from this unique prospective study of young recreational drug-using mothers are consistent with previous reports of improved psychiatric health after quitting MDMA.
娱乐性药物 MDMA（3,4-亚甲基二氧甲基苯丙胺）或“摇头丸”与精神困扰和抑郁感增加有关。婴儿与毒品研究（DAISY）监测了怀孕期间使用摇头丸/ MDMA 的母亲的精神症状谱，并在产后第一年对她们进行了随访。
我们将 28 名在怀孕期间服用 MDMA 的年轻女性与 68 名在怀孕期间服用其他精神活性药物的多药对照组进行了比较。使用 Brief Symptom Inventory（BSI）在几个时间段进行评估：怀孕的第一个三个月；以及产后 1、4 和 12 个月。在每个时间点监测娱乐性药物的使用情况。
在怀孕的第一个三个月，服用 MDMA 的母亲报告的抑郁评分高于多药对照组。在产后 1 年，她们的 BSI 抑郁评分显著降低，现在更接近对照组的值。与此同时，她们自我报告的 MDMA 使用量几乎为零，而她们继续使用大麻/大麻、尼古丁和酒精。我们发现，停止使用摇头丸后，BSI 强迫性和人际敏感症状显著减轻。
这项针对年轻娱乐性药物使用者母亲的独特前瞻性研究的结果与以前关于停止使用 MDMA 后精神健康状况改善的报告一致。
