Dickson D W, Yen S H, Suzuki K I, Davies P, Garcia J H, Hirano A
Acta Neuropathol. 1986;71(3-4):216-23. doi: 10.1007/BF00688042.
Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.
气球样神经元是几种中枢神经系统神经退行性疾病的组织学特征。我们描述了皮克病、未分类痴呆、皮质黑质变性、色素球样变性和阿尔茨海默病中气球样神经元的免疫细胞化学染色。在所有这些情况下，气球样神经元都含有被抗神经丝单克隆抗体识别的磷酸化表位，但不含有阿尔茨海默病神经原纤维缠结和皮克小体特有的表位。这些疾病中气球样神经元的形态特征和免疫组化特性与损害神经丝轴浆运输的神经毒素所产生的肿胀神经元相似。类推而言，这一发现表明神经丝轴浆运输受损可能是各种痴呆性神经退行性疾病的共同机制。
