Nielsen E H, Johansen T
Acta Pharmacol Toxicol (Copenh). 1986 Sep;59(3):214-9. doi: 10.1111/j.1600-0773.1986.tb00157.x.
Nocodazole depolymerized microtubules and increased the number of microfilaments, and dimethylsulfoxide increased the number of microfilaments. Both drugs inhibited compound 48/80-induced histamine release from rat mast cells. Taxol, which increased the number of microtubules, had no effect on histamine release. These observations support the view that microtubules may not be directly involved in secretion, but apparently an increased number of microfilaments is associated with a decreased capacity of the mast cells for histamine release. We suggest that microfilaments have to be depolymerized or rearranged before secretion can take place.
诺考达唑使微管解聚并增加了微丝的数量，二甲基亚砜增加了微丝的数量。两种药物均抑制了化合物48/80诱导的大鼠肥大细胞组胺释放。紫杉醇增加了微管的数量，但对组胺释放没有影响。这些观察结果支持这样一种观点，即微管可能不直接参与分泌，但显然微丝数量的增加与肥大细胞组胺释放能力的降低有关。我们认为，在分泌发生之前，微丝必须解聚或重新排列。
